Reference

Synthesis and protective effect of 1,3,5-triazine derivatives, leukotriene C4 antagonist, on hydrochloric acid ethanol-induced gastric lesions in rats

Synthesis and protective effect of 1,3,5-triazine derivatives, leukotriene C4 antagonist, on hydrochloric acid ethanol-induced gastric lesions in rats. Hasegawa, Yoshihiro; Yanagisawa, Toshihiko; Okui, Yuka; Sato, Toshitsugu; Hosaka, Kunio; Chin, Masao; Mitsuhashi, Hiroshi (Res. Inst. Biol. Chem., Tsumura Co. Ltd., Ami 300-11, Japan). Chem. Pharm. Bull., 39(12), 3180-2 (English) 1991. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 2,4-Diamino-(E)-6-[2-(3-pyridyl)ethenyl]-1,3,5-triazine (I), leukotriene C4 (LTC4) antagonist, was found to possess a protective effect on HCl×ethanol-induced gastric lesions. 139979-29-6 and 454-89-7 which are cas registry numbers of chemicals are mentioned. Analogs of I were synthesized and evaluated for the effect as well as antagonistic activity against LTC4-induced contraction. Thus, diaminomethyltriazine II condensed with RR1C6H3CHO (R = H, 2-CF3, 4-OMe, 4-cyano, etc., R1 = H; R = 2-Cl, R1 = 4-Cl, 6-Cl; R = 3-Cl, R1 = 5-Cl) to give styryltriazines III. Seven compds. exhibited a potent protective effect on gastric lesions which was considered to be based on the antagonistic activity against LTC4. The structure-activity relationships are discussed. .

1-(p-Alkanoylphenyl) alkanols and derivatives

1-(p-Alkanoylphenyl) alkanols and derivatives. Anderson, Paul L.; Nadelson, Jeffrey (Sandoz, Inc., USA). U.S. US 4051261 27 Sep 1977, 9 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07C049-82. NCL: 424331000.Some chemicals with cas registry numbers like 454-89-7 are also used. APPLICATION: US 74-432832 14 Jan 1974. 454-89-7 which is the cas registry number of some chemical is mentioned. DOCUMENT TYPE: Patent CA Section: 25 (Noncondensed Aromatic Compounds) Alcs. I [R = alkyl, cycloalkyl, C6H4R3; R1 = H, alkyl, alkenyl, C6H4R3; R2 = H, Br, Cl, F; R3 = H,Br, Cl, F, CF3; one of Q and Q1 is CO and the other is CH(OH)], which have hypolipemic and antidiabetic activity (the latter in both adults and juveniles), were prepd. Thus, 4-BrCH2C6H4COCMe3 was treated with AcOK in AcOH and the resultant 4-AcOCH2C6H4COCMe3 was sapond. to give 4-HOCH2C6H4COCMe3, effective as an antidiabetic at 10-200 mg/kg body wt. ..