Reference

Synergistic effect of retinoic acid on DNA synthesis by prostaglandin F2a stimulated Swiss 3T3 cells

Synergistic effect of retinoic acid on DNA synthesis by prostaglandin F2a stimulated Swiss 3T3 cells. Eschenbruch, M.; Otto, A. M.; Jimenez de Asua, L. (Friedrich Miescher-Inst., Basel CH-4002, Switz.). Horm. Defined Media, Lect. Posters Eur. Conf. Serum-Free Cell Cult., 1st, Meeting Date 1982, 107-10. Edited by: Fischer, Guenther; Wieser, R. J. Springer: Berlin, Fed. Rep. Ger. (English) 1983. CODEN: 50TEA4. DOCUMENT TYPE: Conference CA Section: 2 (Mammalian Hormones) Retinoic acid [302-79-4] and its analogs (13-cis-retinoic acid [4759-48-2], retinyl acetate [127-47-9], trimethylmethoxyphenyl acid [55079-83-9], arotinoid ethylamide [71441-29-7], and an arotinoid keto deriv.) enhanced the effect of PGF2a [551-11-1] and insulin [9004-10-8] on DNA formation and cell division by Swiss mouse 3T3 cells. This synergy was unaffected by PGE1 or PGE2. Indomethacin had no effect on the synergy of retinoic acid with PGF2a indicating that retinoic acid did not exert its effect by increasing prostaglandin synthesis. Possible explanations for the synergistic effect of retinoic acid are given.

Prevention of 3-methylcholanthrene-induced skin tumors in mice by simultaneous application of 13-cis-retinoic acid and retinyl palmitate (vitamin A palmitate)

Prevention of 3-methylcholanthrene-induced skin tumors in mice by simultaneous application of 13-cis-retinoic acid and retinyl palmitate (vitamin A palmitate). Abdel-Galil, A. M.; Wrba, H.; El-Mofty, M. M. (Inst. Cancer Res., Univ. Vienna, Vienna A-1090, Austria). Exp. Pathol., 25(2), 97-102 (English) 1984. CODEN: EXPADD. ISSN: 0232-1513. 79-81-2 and 56-49-5 are cas registry numbers of chemicals which are used as reagents here. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Section cross-reference(s): 1 Two retinoids (13-cis-retinoic acid [4759-48-2] and retinyl palmitate [79-81-2]) were preventive in chem. induced papillomas and carcinomas of the skin in female Swiss mice, investigated over a period of 23 wk. The tumors were induced by repeated topical application of 3-methylcholanthrene [56-49-5] (0.3% MCA, dissolved in acetone; 14 applications). Retinyl palmitate (6 mg in 0.1 mL acetone/mouse; 10 applications) and 13-cis-retinoic acid (3 mg in 0.1 mL acetone/mouse; 10 applications) were also administered topically for the 3rd to 9th week from the start of the expt. This investigation gave evidence for the fact that both retinoids not only inhibited the development of skin papillomas but had also a marked effect on skin carcinomas. .