Detail of "476-70-0"

Reference

Effects of catecholamine-related mammalian alkaloids on spontaneous and vasopressin-induced behavior in mice

Effects of catecholamine-related mammalian alkaloids on spontaneous and vasopressin-induced behavior in mice. Meisenberg, Gerhard; Simmons, William H.; Collins, Michael A. (Stritch Sch. Med., Loyola Univ., Maywood, IL 60153, USA). Pharmacol., Biochem. Behav., 20(3), 355-60 (English) 1984. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The effects of a variety of simple isoquinolines, benzyl isoquinolines, bicyclic isoquinoline-derived alkaloids (pavines and isopavines), boldine [476-70-0], and berberine [2086-83-1] were investigated after intracerebroventricular injection in mice. Most (13) of the alkaloids studied induced significant alterations in 3 behavioral parameters (immobility, grooming, and scratching behavior).There are some commonly used reagents with their cas registry numbers 90044-47-6 and 90044-48-7 in this article. In addn., the stereotypic scratching behavior elicited by central injection of arginine-vasopressin [113-79-1] was significantly antagonized by only 1 of these, (±)-6-O-methyltetrahydropapaveroline (6-O-methyl-THP) [64710-33-4]. To a lesser extent (-)THP [57073-15-1] and the pavine, (±)bisnorargemonine [29944-24-9], were also effective. That this rather specific alkaloid effect did not involve opioid receptors was indicated by the failure of naloxone to reverse the antagonism by 6-O-methyl-THP. .

Activity of boldine on rat ileum

Activity of boldine on rat ileum. Speisky, H.; Squella, J. A.; Nunez-Vergara, Luis J. (Nutr. Food Technol. Inst., Univ. Chile, Santiago, Chile). Planta Med., 57(6), 519-22 (English) 1991. CODEN: PLMEAA. ISSN: 0032-0943. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Boldine shows a concn.-dependent relaxation effect on the rat ileum prepn. with a pD2 of 3.77. The alkaloid also produces a concn.-dependent parallel shift of the curve-response to acetylcholine, therefore it directly interferes with the cholinergic mechanism assocd. with the cnotraction, behaving as a competitive antagonist with a pA2 of 4. 476-70-0 which is the cas registry number of one of substances is just one of reagents here.78. On the other hand, boldine produces a non=parallel shift of the contraction response induced by barium, revealing the occurrence of a non-competitive antagonism. This effect could be the result of interference with intracellular events assocd. with the barium-induced changes in calcium pools. .