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Basic Information
| CAS No.: | 493-53-8 |
|---|---|
| Name: | sodium O-acetylsalicylate |
| Article Data: | 9 |
| Molecular Structure: | |
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|
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| Formula: | C9H8 O4 . Na |
| Molecular Weight: | 202.142 |
| Synonyms: | Benzoicacid, 2-(acetyloxy)-, sodium salt (9CI); Salicylic acid acetate, sodium salt(8CI); Acetylsalicylate sodium; Acetylsalicylic acid, sodium salt; Aspirinsodium salt; Sodium acetylsalicylate; Sodium acetylsalicylic acid; Sodiumaspirin; Sodium o-acetoxybenzoate; Sodium o-acetyloxybenzoate; Sodiumsalicylate (NaO3C7H5), acetate |
| Density: | g/cm3 |
| Melting Point: | 218 °C |
| Boiling Point: | 321.4°Cat760mmHg |
| Flash Point: | 131.2°C |
| Safety: | Moderately toxic by intraperitoneal and subcutaneous routes. Human systemic effects by intravenous route: unspecified changes in the blood. When heated to decomposition it emits toxic fumes of Na2O. See also ACETOL. |
| PSA: | 66.43000 |
| LogP: | -0.02460 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate In water; isopropyl alcohol at 20℃; for 3h; | 88% |
| With sodium hydride In N,N-dimethyl-formamide for 0.5h; | |
| With sodium carbonate |
Conditions
| Conditions | Yield |
|---|---|
| With water |
Conditions
| Conditions | Yield |
|---|---|
| With acetic acid ester | |
| With methanol | |
| With methanol | |
| With acetic acid ester |
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water | |
| With sodium hydroxide In water |
...Expand
- 493-53-8
sodium O-acetylsalicylate
- 294868-46-5
(OH)2Ti(IV)(acetylsalicylate)2
Conditions
| Conditions | Yield |
|---|---|
| 92% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-diethylamino-propyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform for 0.5h; Stage #2: sodium acetate In chloroform for 2h; Product distribution / selectivity; | 81.6% |
- 127-09-3
sodium acetate
- 22511-39-3
2-dipropylaminoethyl bromide hydrobromide
- 493-53-8
sodium O-acetylsalicylate
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h; Stage #2: sodium acetate In chloroform for 2h; | 81.6% |
| Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h; Stage #2: sodium acetate In chloroform for 2h; | 81.6% |
| Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h; Stage #2: sodium acetate In chloroform at 20℃; for 2h; |
...Expand
- 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
- 493-53-8
sodium O-acetylsalicylate
Conditions
| Conditions | Yield |
|---|---|
| In methanol at 20℃; for 2.5h; Schlenk technique; Inert atmosphere; | 79% |
Conditions
| Conditions | Yield |
|---|---|
| In benzene Na salt and Ti complex refluxed in benzene for 15 h; cooled to room temp., filtered, filtrate concd. in vac., petroleum ether added, placed in refrigerator overnight, filtered, dried in vac. desiccator over P4O10 for 30 h, elem. anal.; | 78% |
| In benzene a mixt. of (η-C5H5)2TiCl2 and Na salt of the substituted benzoic acid in anhydrous benzene stirred at 30°C for 4 h; orange soln. filtered, concd., crystn. (refrigerator), recrystd. (benzene); | 7% |
| In not given |
Conditions
| Conditions | Yield |
|---|---|
| In ethanol Reflux; | 74% |
Downstream Products
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sodium O-acetylsalicylate
Chemistry
O-acetylsalicylic acid, sodium salt has some synonyms like sodium O-acetylsalicylate;2-(Acetyloxy)benzoic acid sodium salt;2-Acetyloxybenzoic acid sodium salt,etc.
Molecular Formula: C9H7NaO4
Molecular Weight: 202.13925
EINECS: 207-777-7
Toxicity Data With Reference
| 1. | ivn-hmn TDLo:306 µg/kg:BLD | GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent Office, Science Library, 2021 Jefferson Davis Highway, Arlington, VA 22202) #2810425 . | ||
| 2. | ipr-rat LD50:1450 mg/kg | NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 79 (1982),357. | ||
| 3. | scu-mus LDLo:700 mg/kg | HDTU** Pharmakologische Prufung von Analgetika, Gunter Herrlen Dissertation. (Pharmakologischen Institut der Universitat Tubingen, Germany, 1933)1933. | ||
| 4. | ipr-mus LDLo:500 mg/kg | JACSAT Journal of the American Chemical Society. 63 (1941),1437. | ||
| 5. | scu-frg LDLo:909 mg/kg | HBAMAK Abdernalden’s Handbuch der Biologischen Arbeitsmethoden. 4 (1935),1290. |
Safety Profile
O-acetylsalicylic acid, sodium salt was moderately toxic by intraperitoneal and subcutaneous routes. Human systemic effects by intravenous route: unspecified changes in the blood. When heated to decomposition it emits toxic fumes of Na2O. See also ACETOL.
Specification
Storage and transport characteristics:storage house needs to be ventilated ,at low-temperature and dry;O-acetylsalicylic acid, sodium salt are kept separately with oxidants, acids, food chemical additives.
Extinguishing agent:
Water mist, foam, carbon dioxide, sand