Detail of "50-91-9"

CAS Number:
50-91-9
Name:
Floxuridine
Molecular Structure:
Formula:
C₉H₁₁FN₂O₅
Molecular Weight:
246.19
Synonyms:
1-(2-Deoxy-b-D-ribofuranosyl)-5-fluorouracil;5-Fluoro-2'-deoxy-b-uridine;5-Fluoro-2'-deoxyuridine;5-Fluorodeoxyuridine;5-Fluorouracil 2'-deoxyriboside;5-Fluorouracil deoxyriboside;Floxuridin;NSC 26740;NSC 27640;2'-Deoxy-5-fluorouridine;
EINECS:
200-072-5
Density:
1.64 g/cm³
Melting Point:
148 °C(lit.)
Solubility:
soluble in water
Appearance:
white solid
Hazard Symbols:
Xn,T,Xi
Risk Codes:
68-36/37/38-40-20/21/22
Safety:
22-36/37/39-26 Details
Transport Information:
UN 2811 6.1/PG 3

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Reference

Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations: Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations. Tanaka, Masao; Kimura, Kiyoji; Yoshida, Shonen (Dep. Med., Nagoya Natl. Hosp., Nagoya 460, Japan). Cancer Res., 43(11), 5145-50 (English) 1983. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Exposure of HL-60 human promyelocytic leukemia cells to 0.5 mM 3H-labeled 5-fluoro-2'-deoxyuridine (FdUrd) [50-91-9] for 16 h resulted in the incorporation of 5.In this article, certain chemicals are used. Some of their cas registry numbers are 50-89-5 and 134-46-3 14 ′ 10-7 mol FdUrd into DNA per mol of DNA nucleotide. Pretreatment with 50 mM thymidine [50-89-5] for 24 h led to a 2.7-fold increase in the incorporation of this analog into newly synthesized DNA during the ensuing 16-h exposure to 0.5 mM [3H]FdUrd. Pretreatment with 0.5 mM methotrexate [59-05-2] for 3 h also increased the [3H]FdUrd incorporation into newly synthesized DNA approx. 5-fold. The presence of either thymidine or methotrexate with [3H]FdUrd, however, decreased incorporation of FdUrd into DNA. More than 50% of the radioactivity in the DNA sepd. by Cs2SO4 equil. d. gradient centrifugation was proven to be fluorodeoxyuridylate [134-46-3] by means of its binding to Lactobacillus casei thymidine monophosphate synthetase. .

Enhanced sensitivity of the C3H/10T1/2 cell transformation system to alkylating and chemotherapeutic agents by treatment with 12-O-tetradecanoylphorbol 13-acetate: Enhanced sensitivity of the C3H/10T1/2 cell transformation system to alkylating and chemotherapeutic agents by treatment with 12-O-tetradecanoylphorbol 13-acetate. Frazelle, Janet H.; Abernethy, Diane J.; Boreiko, Craig J. (Dep. Genet. Toxicol., Chem. Ind. Inst. Toxicol., Research Triangle Park, NC 27709, USA). Environ. Mutagen., 6(1), 81-9 (English) 1984. 759-73-9 and 50-07-7 which are cas registry numbers are also used here. CODEN: ENMUDM. ISSN: 0192-2521. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 The ability of TPA (I) [16561-29-8] to enhance transformation was examd. in C3H/10T1/2 cultures treated with a variety of chem. agents. The addn. of TPA after chem. treatment enhanced the transformation of these cells by Me methanesulfonate [66-27-3], Et methanesulfonate [62-50-0], N-methyl-N'-nitro-N-nitrosoguanidine [70-25-7], N-nitrosomethylurea [684-93-5], N-nitrosoethylurea [759-73-9], mitomycin C [50-07-7], 5-fluorodeoxyuridine [50-91-9], and 5-azacytidine [320-67-2]. Treatment with amethopterin [59-05-2] or benzo[e]pyrene [192-97-2] did not produce significant nos. of foci in the presence or absence of TPA. TPA inhibited transformation by high concns. of 3-methylcholanthrene [56-49-5] and benzo[a]pyrene [50-32-8]. Thus, numerous carcinogens function as initiating agents for these cells and the presence of TPA can dramatically increase the sensitivity of this cell transformation system. .

Detail of "50-91-9"

Floxuridine

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CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

CAS No.50-91-9 Floxuridine

Reference