Reference

Preparation of alkyl 2-(3-tetrahydrofurylmethyl)penem-3-carboxylates with improved bioavailability

Preparation of alkyl 2-(3-tetrahydrofurylmethyl)penem-3-carboxylates with improved bioavailability. Iwata, Hiromitsu; Nakatsuka, Takashi; Tanaka, Rie; Ishiguro, Masaji (Suntory, Ltd., Japan). PCT Int. Appl. WO 9203444 A1 5 Mar 1992, 26 pp. DESIGNATED STATES: W: AU, BG, BR, CA, CS, FI, HU, JP, KR, MC, NO, PL, RO, SU, US; RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D499-88. ICS: A61K031-43. APPLICATION: WO 91-JP1100 16 Aug 1991. PRIORITY: JP 90-218543 20 Aug 1990. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 1 Title compds. [I; R = CHR1OCOnR2, Q1; R1 = alkyl; R2, R3 = (substituted) alkyl, aryl, aralkyl; n = 1,2] were prepd. as antibiotics (no data). Thus, a mixt. of Na (5R, 6S)-6-[(R)-1-hydroxyethyl]-2-(3-tetrahydrofuryl)methylpenem-3-carboxyl ate, 1-chloroethyl cyclohexylcarbonate, and DMF was heated at 70° for 1 h to give I [R = 1-(cyclohexyloxycarbonyloxy)ethyl]. Urinary recovery of I in rats was 20.In this experiment, several chemicals are used like 80841-79-8 and 53064-79-2 97-35.55%. .