Reference

2-(4-Aminobenzenesulfonamido)-4-methyl-pyrimidine

2-(4-Aminobenzenesulfonamido)-4-methyl-pyrimidine.Some chemicals with cas registry numbers like 5436-21-5 and 57-67-0 are also used. Giermasinski, Jakub; Kaczorek, Jadwiga; Kycia, Henryk; Stefaniak, Ferdynand; Surgiewicz, Janusz (Grodziskie Zaklady Farmaceutyczne "Polfa", Pol.). Pol. PL 77666 31 Oct 1975, 2 pp. (Polish). (Poland). CODEN: POXXA7. CLASS: IC: C07D051-44. APPLICATION: PL 69-132210 8 Mar 1969. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The yield of the title compd., prepd. by condensation of p-aminobenzenesulfonamidoguanidine with Me or Et acetal of formylacetone, was increased to 90% by addn. of a water-combining agent, such as anhyd. K2CO3, Na2CO3, AcONa or CaO. .

Measurement of plasma etoposide by radioimmunoassay

Measurement of plasma etoposide by radioimmunoassay. Yamashita, Kouwa; Watanabe, Keiko; Takayama, Hideki; Ishibashi, Masataka; Miyazaki, Hiroshi (Pharm. Div.In this study， 107465-00-9 and 5436-21-5 are also used., Nippon Kayaku Co., Tokyo 115, Japan). J. Pharm. Biomed. Anal., 5(1), 11-20 (English) 1987. CODEN: JPBADA. ISSN: 0731-7085. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A sensitive RIA for the specific detn. of etoposide [33419-42-0] in human plasma is described. In order to obtain a specific antisera, etoposide-acetonylcarboxymethoxime-bovine serum albumin (BSA) and etoposide-hemisuccinate-BSA conjugates were synthesized as antigenic hapten carrier proteins. Antisera raised against both conjugates in rabbits and sheep exhibited high specificity and made it possible to discriminate etoposide from picro-etoposide and picro-hydroxy acid. Good correlation was found in a comparison of the new RIA method with 1 method involving HPLC. The method was applied to the direct anal. of etoposide in the plasma obtained from cancer patients. .