Detail of "545-55-1"

Reference

Chromosome aberrations associated with tri and difunctional aziridine groups containing chemosterilants, TEPA and ENT 50787

Chromosome aberrations associated with tri and difunctional aziridine groups containing chemosterilants, TEPA and ENT 50787. Manna, G. K.; Das, P. K. (Dep. Zool., Kalyani Univ., Kalyani, India). Nucleus (Calcutta), 19(2), 106-12 (English) 1976. CODEN: NULSAK. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effect of the insect chemosterilants, tepa (I) [545-55-1] and ENT 50787 [302-48-7], on chromosome aberrations in the bone marrow cells was studied in mice after i.p. administration. Of 3600 metaphases examd. in I-treated animals, 1023 were affected; of these, 847 showed gross effects on chromosomes and the rest had individual types of aberrations. Of 1900 metaphases examd. in the ENT 50787-treated series, 39% were affected; of these, 34.8% had gross effects. Anal. of the group-wise and region-wise distribution of chromatid breaks induced by the 2 chemosterilants revealed that they were nonrandomly distributed. Chromosomes belonging to groups I and II were more susceptible than the rest of the groups;, and the mid-region of the affected chromatids was most vulnerable, whereas the proximal region was less sensitive. The possible mechanism of chromosome aberration induced by the chemosterilants is discussed.

In the search for new anticancer drugs

In the search for new anticancer drugs. XX: A comparison of the in vitro growth inhibition of P388 cells by TEPA and N,N;N',N'-bis(1,2-ethanediyl)-N"-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl aminocarbonyl)phosphoric triamide and congeners. Miller, Birgitta; Sosnovsky, George; Rao, N. Uma Maheswara; Gutierrez, Peter L. (Cancer Cent. 96662-65-6 and 96662-66-7 are also occured in this study., Univ. Maryland, Baltimore, MD 21201, USA). Cancer Lett. (Shannon, Irel.), 34(1), 3-8 (English) 1987. CODEN: CALEDQ. ISSN: 0304-3835. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The in vitro growth-inhibitory activity of TEPA [545-55-1] and 3 analogs were tested against P388 murine lymphocytic leukemia cells in culture. The analogs consist of spin-labeled TEPA and 2 reduced forms contg. the NH and NOH groups instead of the nitroxyl function. Spin-label TEPA was obtained by replacing one of the aziridine groups in TEPA with spin-labeled urea. In a concn. range 10-6-10-5M, only the reduced analog contg. the NH group was active. To achieve a 50% inhibition of cell growth, a 5-fold excess in concn. of this analog (IC50 = 10 ′ 10-6M) was needed as compared to the parent compd. TEPA (IC50 = 2 ′ 10-6M). These results are in contrast with those obtained in vivo against the same leukemia cell line, indicating inherent discrepancies between in vivo and in vitro evaluation of antitumor agents. .