Reference

Effect of delta-aminolevulinic acid on the resting membrane potential of frog sartorius muscle

Effect of delta-aminolevulinic acid on the resting membrane potential of frog sartorius muscle. Becker, D. M.; Goldstuck, N.; Kramer, S. (Sch. Pathol., Univ. Witwatersrand, Johannesburg, S. Afr.). S. Afr. Med. J., 49(43), 1790-2 (English) 1975. CODEN: SAMJAF. ISSN: 0038-2469. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) d-Aminolevulinic acid-HCl [5451-09-2] decreased the resting membrane potential in frog muscle fibers, apparently by altering the membrane permeability to Na+ and K+. The depolarizing effect of the porphyrin precursor was dose dependent and reversible, and probably involved unknown mechanisms in addn. to the inhibition of Na+, K+-dependent ATPase. The possible role of d-aminolevulinic acid in the prodn. of the neurol. manifestations of porphyria are discussed.

Effects of light fractionation and different fluence rates on photodynamic therapy with 5-aminolaevulinic acid in vivo

Effects of light fractionation and different fluence rates on photodynamic therapy with 5-aminolaevulinic acid in vivo. Babilas, P.; Schacht, V.; Liebsch, G.; Wolfbeis, O. S.; Landthaler, M.; Szeimies, R.-M.; Abels, C. 5451-09-2 is the cas registry number. This chemical is also mentioned in this article. (Department of Dermatology, University of Regensburg, Regensburg 93042, Germany). British Journal of Cancer, 88(9), 1462-1469 (English) 2003 Nature Publishing Group. CODEN: BJCAAI. ISSN: 0007-0920. DOCUMENT TYPE: Journal CA Section: 8 (Radiation Biochemistry) To improve efficacy of photodynamic therapy (PDT) with i.v. administered 5-aminolaevulinic acid (ALA) fractionating the light dose or reducing the light intensity may be a possibility. Therefore, Syrian Golden hamsters were fitted with dorsal skinfold chambers contg. an a melanotic melanoma (n=26). PDT was performed (100 mW cm-2, 100 J cm-2, continuously or fractionated, and 25 mW cm-2, 100 J cm-2; continuously or fractionated) using an incoherent light source following i.v. application of ALA. Following fractionated irradn., the light was paused after 20 J cm-2 for 15 min. Prior to and up to 24 h after PDT tissue, pO2 was measured using luminescence lifetime imaging. The efficacy was evaluated by measuring the tumor vol. of a melanotic melanoma cells grown s.c. in the back of Syrian Golden hamsters (n=36). Only high-dose PDT resulted in a significant decrease of pO2. Irresp. of the mode of irradn. only high-dose PDT induced complete remission of all tumors (13 out of 13). It could be shown that low-dose PDT failed to induce a significant decrease of pO2. No significant effect of fractionated irradn. was shown regarding the therapeutic efficacy 28 days after PDT. Thus performing a fractionated PDT with ALA or reducing the light intensity seems not to be successful in clin. PDT according to the present data. .