Reference

Intravenous liothyronine sodium (T3) for myxedema coma - pharmaceutical considerations

Intravenous liothyronine sodium (T3) for myxedema coma - pharmaceutical considerations. Odgers, Christine L.; Phillips, Patrick J.; Shanks, Gary (Dep. Pharm., Flinders Med. Cent., Bedford 5042, Australia). Aust. J. Hosp. Pharm., 14(4), 181-8 (English) 1984. CODEN: AUHPAI. ISSN: 0310-6810. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 2 The stability of liothyronine Na (I) [55-06-1] in dil. aq. solns. was studied in static and dynamic infusion systems composed of glass and different plastic materials to det. the feasibility of administering parenteral I by intermittent i.v. infusion over a period of 1-2 h. The effect of H+ concn. and the incorporation of drug carriers into the infusion vehicle on the stability of I was investigated. In the static systems, the I concn. decreased rapidly following addn. of a 20 mg/2 mL soln. to 50-100 mL NaCl solns. of varying pH. The rate of loss decreased with time, and was indicative of adsorption to the plastics, cellulose propionate [9004-48-2], PVC [9002-86-2], and polypropylene [9003-07-0], present in the system. The rate of loss of I was greater in the dynamic systems than the static systems, and the extent of loss was affected by the nature of the various components of the fluid pathway. Minimal losses occurred when more concd. solns. (20 mg I/50 mL) were infused by using polypropylene syringes and min. vol. PVC extension tubes as the components of the infusion system. The loss was further minimized by the addn. of drug carriers to the NaCl vehicle, with minimal loss occurring with 2% wt./vol. albumin.

Effect of triiodothyronine and methylthiouracil on the activity of some enzymes secondary to metabolism of biogenic amines in synaptosomes of rat brain

Effect of triiodothyronine and methylthiouracil on the activity of some enzymes secondary to metabolism of biogenic amines in synaptosomes of rat brain. Savitskii, S. Yu.; Kononenko, V. Ya. (Kiev. Nauchno-Issled. Inst. Endokrinol., Kiev, USSR). Farmakol. Toksikol. (Moscow), 41(1), 60-3 (Russian) 1978. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Exptl. hyperthyroidism in rats caused by triiodothyronine Na salt (I Na salt) [55-06-1] (12.5 mg/100 g/day for 15 days, s.c.) was characterized by a decrease in the intensity of decarboxylation of dopa [59-92-7] and 5-hydroxytryptophan [56-69-9] and of oxidative deamination of serotonin [50-67-9] and noradrenaline [51-41-2] in brain synaptosomes. During exptl. hypothyroidism caused by methylthiouracil, DOPA decarboxylation and monoamine deamination were increased but 5-hydroxytryptophan decarboxylation was not affected.