Reference

Pharmaceutical agent promoting blood circulation

Pharmaceutical agent promoting blood circulation. Materne, Carsten; Betzing, Hans (Nattermann, A., und Cie. G.m.b.H., Ger.). Ger. Offen. DE 2659666 13 Jul 1978, 5 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-44. APPLICATION: DE 76-2659666 30 Dec 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 27 Circulation-promoting agents comprise 10-60 mg/dosage unit of I (R = Et) or Me 2,6-dimethyl-3-cyano-4-(2-nitrophenyl)-1,4-dihydropyridine-5-carboxylat e (I; R = Me) [67587-23-9] or a mixt. of these 2 compds. For example, 2-nitrobenzaldehyde [552-89-6] was treated with aminocrotonic acid nitrile [1118-61-2] and Me aminocrotonate [14205-39-1] in EtOH in the presence of AcOH to give I (R = Me) in 58% yield. The compd. was recrystd. and placed in gelatin capsules in dosages of 30 mg/capsule.

Toxicity of sneezing powders

Toxicity of sneezing powders. Part I. Study on forbidden constituents in sneezing powders. Charles, M. H.; Grimee, R.; Crucke, F. (Serv. Anal. Med., Inst. Hyg. Epidemiol., Brussels 1050, Belg.). J. Pharm. Belg., 39(6), 371-9 (French) 1984. CODEN: JPBEAJ. ISSN: 0047-2166. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) In 46 com. samples of sneezing powders, 3,3'-dimethoxybenzidine (I) [119-90-4], 3,3'-dimethylbenzidine [119-93-7], o-nitrobenzaldehyde [552-89-6], alkaloids, protoveratrine A [143-57-7], and B [124-97-0] in exts. of the roots of Veratrum album, quillaic acid [631-01-6] in exts. from Panama wood (Quillaia saponaria), and piperine [94-62-2] in exts. from pepper were identified by TLC, UV spectrometry, NMR, HPLC, and by microscopic anal. of the plant powders. The powders caused several severe poisonings in children and are too dangerous for use as toys.