Reference

Nucleotide requirement of dopamine sensitive adenylate cyclase in synaptosomal membranes from the striatum of rat brain

Nucleotide requirement of dopamine sensitive adenylate cyclase in synaptosomal membranes from the striatum of rat brain. Roufogalis, B. D.; Thornton, M.; Wade, D. N.Chemicals with cas numbers 118-00-3 and 34273-04-6 also play role. (Dep. Clin. Pharmacol., St. Vincent's Hosp., Sydney, Aust.). J. Neurochem., 27(6), 1533-5 (English) 1976. CODEN: JONRA9. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 7 Dopamine [62-31-7] stimulation of basal adenylate cyclase (I) [9012-42-4] activity in synaptosomal membranes from rat brain striatum was not obsd. unless GTP [86-01-1] was added to the medium, 10.mu.M GTP giving the max. slope on the dopamine concn.-response curve. Guanyl-5'-yl imidodiphosphate [34273-04-6] was more effective than GTP in stimulating basal I activity and enhancing its dopamine sensitivity. Adenine nucleotides may promote the conversion of a ground state of I to an active transition state complex, and hormones may act by enhancing the rate limiting step in the process of nucleotide activation of I. .

Tremorogenic effects of intracaudate d-amphetamine and their suppression by dopamine

Tremorogenic effects of intracaudate d-amphetamine and their suppression by dopamine. Baker, W. W.; Zivanovic, D.; Malseed, R. T. (Div. Neuropharmacol., East. Pennsylvania Psychiatr. Inst., Philadelphia, Pa., USA). Arch. Int. Pharmacodyn. Ther., 223(2), 271-81 (English) 1976. CODEN: AIPTAK. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 Pronounced tremors were produced in unanesthetized cats following intracaudate (I.C.) injections of either d-amphetamine phosphate [7528-00-9] (15 .mu.g), dl-methamphetamine-HCl [4298-16-2] (20 .mu.g), l-amphetamine sulfate [51-62-7] (48 .mu.g) or 3-methoxytyramine-HCl [34536-15-7] (68-120 .mu.g). Yet, a series of other chem. and pharmacol. related phenylethylamines, including dopamine-HCl (I-HCl) [62-31-7] (90 .mu.g), were not tremorogenic even at substantially higher doses. The d-amphetamine tremors developed rapidly, failed to exhibit tachyphylaxis to repeated challenging doses (15 .mu.g) and were not influenced by pretreatment with .alpha.-methyl-p-tyrosine. They also developed independently of local acetylcholine activity as evidenced by the inability of cholinergic antagonists (scopolamine and hemicholinium) to interfere with the tremors. Significant qual. differences were found between the I.C. effects of d-amphetamine (15 .mu.g) and I (15-90 .mu.g): d-amphetamine further increased the intensity of ongoing tremors induced by physostigmine salicylate [57-64-7] (111 .mu.g I.C.In this experiment, several chemicals are used like 57-64-7 and 7528-00-9 ), whereas, dopamine readily inhibited the latter. When superimposed, I.C., I was equally effective in suppressing d-amphetamine tremor activity. The results emphasize the selective tremorogenic actions of d-amphetamine and call attention to the contrasting stabilizing role of I. This would suggest that 2 types of adrenergic receptor sites are operative in the caudate in neuroregulation of involuntary movements. .