Reference

Comparative study of the protective effect of an anabolic steroid

Comparative study of the protective effect of an anabolic steroid. The 19-nortestosterone-phenylpropionate (19 NTPP), on liver steatosis induced by Amanita phalloides and white phosphorus in rats. Jacqueson, A.; Thevenin, M.; Warnet, J. M.; Claude, J. R.; Truhaut, R. (Fac. Sci. Pharm. Biol., Univ. R. Descartes Paris, Paris, Fr.). Arch. Toxikol., (Suppl. 1, Toxicol. Aspects Food Saf.), 193-6 (English) 1978. CODEN: ATXKA8. ISSN: 0003-9446. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 14 Toxic fatty liver is often related to the inhibition of the biosynthesis of the protein moiety of hepatic lipoproteins and to the subsequent trouble of the secretion of liver triglycerides (TG). An attempt was made to prevent this biochem. injury by a daily administration of an anabolic steroid: 19-nortestosterone phenylpropionate (I) [62-90-8] (25 mg/kg/24 h, i.p.), to female rates, 8 days before the administration of 2 steatogenic agents: white phosphorus (WP) (10 mg/kg, s.c.) and Amanita phalloides ext. (AP) (0.5 mL/kg, i.p.). The animals were killed 36 h (WP) or 18 h (AP) after poisoning and hepatic lipid components were detd. In both cases, the TG accumulated were responsible for the fatty liver, with 5-6 fold increase as compared with controls. The administration of I provoked a decrease of liver TG in both intoxications, but with different intensity: very marked with AP, moderately marked with WP. Apparently, a much more specific protective effect of I in AP fatty liver, related to the stimulation of RNA polymerase II, inhibited by a-Amanitin; in WP fatty liver, the moderate effect of I may be due to a nonspecific stimulation of the biosynthesis of liver apolipoproteins.

Effect of steroids with antiandrogenic properties on the androgenic and myotrophic activity of testosterone and some of its derivatives

Effect of steroids with antiandrogenic properties on the androgenic and myotrophic activity of testosterone and some of its derivatives. Ivanenko, T. I. (Inst. Eksp. Endokrionol. Khim. Gorm., Moscow, USSR). Probl. Endokrinol., 24(4), 86-91 (Russian) 1978. CODEN: PROEAS. ISSN: 0375-9660. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) 17,17-Dimethyl-13-norandrosta-4,13-diene-3-one (I) [1971-59-1] injected s.c. into castrated rats inhibited the increase in wts. of accessory sex organs and levator ani muscle caused by testosterone [58-22-0] testosterone propionate [57-85-2], 19-nortestosterone [434-22-0], methandrostenolone [72-63-9], and norandrostenolone phenylpropionate [62-90-8]. The antiandrogenic effect of I depended on its dose as well as on the dose of the agonist. A modification of the method used to assess biol. activity of antiandrogens consisted of a single administration of anabolic prepns. with prolonged activity and 7-day administration of the antiandrogen to castrated animals.