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CAS No.: | 63-45-6 |
---|---|
Name: | Primaquine diphosphate |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C15H21N3O.2(H3PO4) |
Molecular Weight: | 455.342 |
Synonyms: | Prestwick_406;[(4S)-4-[(6-methoxyquinolin-8-yl)amino]pentyl]azanium;Primaquine phosphate (USP);Quinoline, 8-[ (4-amino-1-methylbutyl)amino]-6-methoxy-, phosphate (1:2);Primaquine (TN);N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine; phosphoric acid;1,4-Pentanediamine, N4- (6-methoxy-8-quinolinyl)-, phosphate (1:2);primaquine bis(phosphate); |
EINECS: | 200-560-8 |
Melting Point: | 199-205 °C |
Boiling Point: | 451.1 °C at 760 mmHg |
Flash Point: | 226.6 °C |
Solubility: | moderately soluble in water |
Appearance: | orange powder |
Hazard Symbols: | T |
Risk Codes: | 25 |
Safety: | 45 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 235.31000 |
LogP: | 1.69880 |
Conditions | Yield |
---|---|
With phosphoric acid In diethyl ether Darkness; |
Conditions | Yield |
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Multi-step reaction with 5 steps 1: arsenic(V) oxide; phosphoric acid / 1 h / 100 °C / Darkness 2: hydrogen / 2585.81 Torr / Darkness 3: triethylamine / 6 h / 150 °C / Darkness 4: hydrazine / ethanol / 72 h / Reflux; Darkness 5: phosphoric acid / diethyl ether / Darkness View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen / 2585.81 Torr / Darkness 2: triethylamine / 6 h / 150 °C / Darkness 3: hydrazine / ethanol / 72 h / Reflux; Darkness 4: phosphoric acid / diethyl ether / Darkness View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / 6 h / 150 °C / Darkness 2: hydrazine / ethanol / 72 h / Reflux; Darkness 3: phosphoric acid / diethyl ether / Darkness View Scheme |
N-phthalolylprimaquine
primaquine diphosphate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrazine / ethanol / 72 h / Reflux; Darkness 2: phosphoric acid / diethyl ether / Darkness View Scheme |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide 1.) 0 deg C, 4 h, 2.) RT, overnight; | 95% |
2-chloro-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester
primaquine diphosphate
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere; | 95% |
primaquine diphosphate
C15H19(2)H2N3O
Conditions | Yield |
---|---|
With sulfuric acid; water-d2 at 95℃; for 8h; Temperature; | 95% |
2-chloro-4-methyl-6-phenylpyrimidine-5-carboxylic acid ethyl ester
primaquine diphosphate
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1h; | 92% |
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The IUPAC name of Primaquine phosphate is 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine; phosphoric acid. With the CAS registry number 63-45-6 and EINECS 200-560-8, it is also named as (+-)-8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline phosphate (1:2). The classification codes are Antimalarial; Drug / Therapeutic Agent; Mutation data; Reproductive Effect. It is orange powder which is is highly toxic and flammable. When heated to decomposition it emits toxic fumes of NOx and POx. So the storage environment should be well-ventilated, low-temperature and dry.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.53; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.6; (4)ACD/LogD (pH 7.4): -1.19; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 28.6 Å2; (13)Enthalpy of Vaporization: 71.01 kJ/mol; (14)Vapour Pressure: 2.5E-08 mmHg at 25°C; (15)Rotatable Bond Count: 6; (16)Exact Mass: 455.122253; (17)MonoIsotopic Mass: 455.122253; (18)Topological Polar Surface Area: 216; (19)Heavy Atom Count: 29; (20)Complexity: 312.
Uses of Primaquine phosphate: It is an aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It can also be used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. The adverse effects include anemias and GI disturbances.
When you are using this chemical, please be cautious about it as the following:
It is toxic if swallowed. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
People can use the following data to convert to the molecule structure.
1. SMILES:O=P(O)(O)O.O=P(O)(O)O.O(c1cc(NC(C)CCCN)c2ncccc2c1)C
2. InChI:InChI=1/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)
3. InChIKey:GJOHLWZHWQUKAU-UHFFFAOYAE
The following are the toxicity data which has been tested.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - domestic | LD50 | intravenous | 19300ug/kg (19.3mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1775, 1970. | |
mouse | LD50 | intraperitoneal | 105mg/kg (105mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1775, 1970. | |
mouse | LD50 | oral | 68mg/kg (68mg/kg) | Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol. 74, Pg. 43, 1980. | |
rat | LD50 | oral | 177mg/kg (177mg/kg) | Journal of Medicinal Chemistry. Vol. 32, Pg. 1728, 1989. |