Detail of "63527-52-6"

CAS Number:
63527-52-6
Name:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-,(6R,7R)-
Superlist Name:
Cefotaxime
Molecular Structure:
Formula:
C₁₆H₁₇N₅O₇S₂
Molecular Weight:
455.47
Synonyms:
Zeefotax;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-,[6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-,(6R,7R)- (9CI);Cefabol;Cefotaxime acid;Ceftax;Claforan;Omnatax;Taxim;
EINECS:
264-299-1
Density:
1.8 g/cm³
Solubility:
soluble in water
Appearance:
white power

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Stimulation of lymphocyte cell growth in vitro by the cephalosporin-derivatives cefodizime (HR 221) and cefotaxime: Stimulation of lymphocyte cell growth in vitro by the cephalosporin-derivatives cefodizime (HR 221) and cefotaxime. Mueller, W. E. G.; Seibert, G. (Inst. Physiol. Chem., Univ. Mainz, Mainz, Fed. Rep. Ger.). Recent Adv. Chemother., Proc. Int. Congr. 69739-16-8 and 68401-81-0 which are cas registry numbers are also used here. Chemother., 14th, Issue Antimicrobial Sect. 2, 931-2. Edited by: Ishigami, Joji. Univ. Tokyo Press: Tokyo, Japan. (English) 1985. CODEN: 55GNAX. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) The in vitro effect of 3 cephalosporins (cefodizime [69739-16-8], cefotaxime [63527-52-6], and ceftizoxime [68401-81-0]) on the growth of L5178y mouse lymphoma cells, Molt-4 cells, and murine splenic lymphocytes was studied. At 0.1-50 mM, the cephalosporins had no effect on L5178y cell growth. However, Molt-4 cell growth was stimulated by 0.3-20 mM cefotaxime and cefodizime but was not influenced by ceftizoxime. Cefodizime (0.15-50 mM) which was added to mouse spleen cell cultures increased [3H]thymidine incorporation into lymphocytes. .

b-Lactam antibiotics inhibit fibrinogen binding to human platelets in vitro: a model for platelet alteration in vivo: b-Lactam antibiotics inhibit fibrinogen binding to human platelets in vitro: a model for platelet alteration in vivo. Heinrich, D.; Weinel, R.; Santoso, S. (Dep. Intern. Med., Justus Liebig-Univ., Giessen, Fed. Rep. Ger.). Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, Issue Antimicrobial Sect. 3, 2611-12. Edited by: Ishigami, Joji. Univ. Tokyo Press: Tokyo, Japan. (English) 1985. CODEN: 55GNAX. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) To evaluate the inhibitory effect of b-lactam antibiotics on human platelets, fibrinogen binding to platelets was induced by ADP (10-5 M) following 10 min preincubation of platelets with equimolar concns. (10, 1, 0.1 mM) of penicillin G [61-33-6], azlocillin [37091-66-0], piperacillin [61477-96-1], latamoxef [64952-97-2], cefotaxim [63527-52-6], and ceftazidime [72558-82-8]. b-Lactam antibiotics induce a quant. different inhibition of fibrinogen binding to platelets. With respect to plasma concns. reached in vivo, the platelet inhibition is clin. relevant with penicilin G. azlocillin, and latamoxef. For penicillin G platelets remain partially inhibited even after elimination of the drug from the incubation mixt. 72558-82-8 and 61477-96-1 are just another two chemicals used in this study. These results are discussed in relation to bleeding disorders assocd. with b-lactam antibiotics. .