Reference

Inhibition of experimental cholesterol arteriopathy by metformin in rabbits

Inhibition of experimental cholesterol arteriopathy by metformin in rabbits. Weber, G.; Papi, F.; Pescatori, G. F.; Sforza, V.; Losi, M. (Ist. Anat. Istol. Patol., Univ. Siena, Siena, Italy). G. Arterioscler., 1(3), 215-19 (Italian) 1976. CODEN: GIARA5. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The formation of aortic lesions in rabbits due to feeding cholesterol (I) [57-88-5] (2 g/day for 2 months) was almost entirely prevented by simultaneously feeding metformin [657-24-9] (135 mg/kg/day). In other expts., visceral I deposits were produced by a high-I diet together with triweekly injections of Tween 80; when this regime was stopped, I was released from the deposits, causing so-called endogenous aortic lesions. Daily administration of metformin, beginning at the time of stopping the I-Tween 80 regime, also inhibited the formation of the endogenous aortic lesions, although the protection was less marked than in the 1st expts.

The effect of short-term administration of antidiabetic biguanide derivatives on the blood lactate levels in healthy subjects

The effect of short-term administration of antidiabetic biguanide derivatives on the blood lactate levels in healthy subjects. Czyzyk, A.; Lao, B.; Bartosiewicz, W.; Szczepanik, Z.; Orlowska, K. (Dep. Gastroenterol. Metab. Dis., Med. Acad., Warsaw, Pol.). Diabetologia, 14(2), 89-94 (English) 1978. CODEN: DBTGAJ. ISSN: 0012-186X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In 3 groups of healthy subjects, changes in blood lactate [50-21-5], pyruvate [127-17-3], and bicarbonate concns. and pH were detd. during 3 different loading tests. The same tests were repeated after administration of biguanides for 3 days in the following doses: phenformin [114-86-3] 150 mg, buformin [692-13-7] 300 mg, and metformin [657-24-9] 2.55 g daily. All 3 derivs. increased blood lactate levels and the blood lactate/pyruvate ratio. The differences in the effect of individual biguanides were minimal. Increments in blood lactate concns. depended markedly on the type of load given. The highest rise in blood lactate level was found after fructose loading; in the 60th min of the test after phenformin it was 1.60, after buformin 1.32, and after metformin 1.31 mmol/L. The smallest rise of lactate was obsd. after oral EtOH loading: in the 1st h of the test the resp. values were 0.41, 0.52, and 0.91 mmol/L. In the exercise test (15 min submax. exercise load), the highest increment of the blood lactate level was obsd. 15 min after the end of the exercise, being 1.06, 1.21, and 1.26 mmol/L, resp. Thus, all 3 biguanide derivs. used in treatment of diabetes may induce lactic acidosis under suitable conditions.