Detail of "68-96-2"

CAS Number:
68-96-2
Name:
Hydroxyprogesterone
Molecular Structure:
Formula:
C₂₁H₂₀O₃
Molecular Weight:
330.47
Synonyms:
17-Hydroxypregn-4-ene-3,20-dione;17-Hydroxyprogesterone;17a-Hydroxylutin;17a-Hydroxypregn-4-ene-3,20-dione;17a-Hydroxyprogesterone;Gestageno;Gestageno Gador;Pregn-4-en-17a-ol-3,20-dione;Prodix;D4-Pregnen-17a-ol-3,20-dione;
EINECS:
200-699-4
Density:
1.15 g/cm³
Melting Point:
276 °C
Boiling Point:
482.9 °C at 760 mmHg
Flash Point:
259.9 °C
Appearance:
White solid
Hazard Symbols:
Risk Codes:
61
Safety:
53-22-36/37/39-45 Details

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

All Suppliers

Supplier Location
Supplier Location
- China (Mainland)(25)
- Italy(1)
- Macao(1)
- United States(1)
Business Type
Business Type
- Lab/Research institutions(1)
- Manufacturers(6)
- Trading Company(17)
Certificates
Certificates
- Production License(5)
- ISO(1)

Please post your buying leads>>

Display：

Manufacturer
Enterprise Authentication
Suppiers of more reward points first
New supplier

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Reference

High affinity progesterone binding sites of human uterine microsomal membranes: High affinity progesterone binding sites of human uterine microsomal membranes. Haukkamaa, Maija (Dep. Med. Chem., Univ. Helsinki, Helsinki SF-00170, Finland). J. Steroid Biochem., 20(2), 569-73 (English) 1984. CODEN: JSTBBK. ISSN: 0022-4731. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Microsomal membranes sedimented at 40,000 g were prepd. from human myometrium samples. The progesterone [57-83-0]-binding properties of microsomal suspensions were detd. by incubating microsomes and [3H]progesterone at 4°.Several reagents with their cas registry numbers 566-65-4 and 58-22-0 are used here. Dextran-coated charcoal was used for the sepn. of bound and free steroids. Membrane-assocd. progesterone-binding sites of high affinity were identified in microsomes prepd. from pregnant and nonpregnant uteri. The binding was saturable (Kd ~4 ′ 10-9M, concn. of binding sites 400-900 fmol/mg microsomal protein) and specific for natural progesterone. Of 21 steroids tested only 21-hydroxy-4-pregnene-3,20-dione [64-85-7], 17a-hydroxyprogesterone [68-96-2], and testosterone [58-22-0] showed moderate competition against progesterone with relative affinities of 7.0-20.0%. 5a-Dihydroprogesterone [566-65-4] and 5a-dihydrotesterone [521-18-6] showed weak cross reaction (relative affinities 2.5 and 2.0%, resp.). Corticosteroids, estrogens, and the 5 synthetic progestins tested showed only weak competition with relative affinities <1.0%. These microsomal progesterone-binding sites of high affinity and limited capacity resemble steroid hormone receptors but they are different from the sol. cytosolic progesterone receptor of human uterus in terms of steroid specificity. The physiol. function of this microsomal progesterone receptor is unknown. .

Phorbol ester inhibition of ovarian and testicular steroidogenesis in vitro: Phorbol ester inhibition of ovarian and testicular steroidogenesis in vitro. Welsh, Thomas H., Jr.; Jones, Phillip B. C.; Hsueh, Aaron J. W. (Dep. Reprod. Med., Univ. California, San Diego, La Jolla, CA 92093, USA). Cancer Res., 44(3), 885-92 (English) 1984. CODEN: CNREA8. ISSN: 0008-5472.There are some reagents with their cas registry numbers 145-14-2 and 9040-08-8 are used in this study. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 2 Possible influences of the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)(I) [16561-29-8] upon gonadal steroidogenesis were investigated in vitro. Granulosa cells from hypophysectomized, estrogen-treated rats were cultured for 2 days in medium contg. 0.1 mM androstenedione [63-05-8]. The FSH [9002-68-0] treatment increased estrogen, progesterone [57-83-0], and 20a-hydroxypregn-4-en-3-one [145-14-2] prodn. Concomitant TPA treatment inhibited FSH-stimulated estrogen prodn. by up to 95% [concn. that induced 50% inhibition of steroid prodn. (ED50), 1.1 ng/mL]. TPA also inhibited FSH-stimulated progesterone (ED50, ~0.6 ng/mL) and 20a-hydroxypregn-4-en-3-one (ED50, ~1.1 ng/mL) prodn. N6O2'-Dibutyryl cyclic adenosine 3':5'-monophosphate [362-74-3] increased steroidogenesis; however, cotreatment with TPA blocked progestin [57-83-0] but not estrogen prodn. The TPA inhibition of progestin biosynthesis was accompanied by decreases in FSH-stimulated pregnenolone [145-13-1] biosynthesis and 3b-hydroxysteroid dehydrogenase [9015-81-0] activity without decreasing the activity of 20a-hydroxysteroid dehydrogenase [9040-08-8]. In primary cultures of rat testicular cells, human chorionic gonadotropin [9002-61-3] treatment increased testosterone [58-22-0] prodn. 44-fold, whereas concomitant treatment with TPA inhibited testosterone prodn. by up to 86% (ED50, 10 ng/mL). Chlorea toxin and N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate also increased testosterone prodn., while the actions of these agents were decreased by TPA. The TPA suppression of testosterone prodn. was assocd. with a decrease in accumulation of 17a-hydroxyprogesterone [68-96-2] and androstenedione and an increase in progesterone prodn., suggesting a specific inhibition of 17a-hydroxylase [9029-67-8] and 17,20-lyase [9044-50-2] activities. These results demonstrate the inhibitory effects of a tumor promoter upon gonadotropin-stimulated steroidogenesis by cultured rat granulosa and Leydig cells through specific regulation of steroidogenic enzymes. .

Detail of "68-96-2"

Hydroxyprogesterone

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

CAS No.68-96-2 Hydroxyprogesterone

Reference