Products Categories
CAS No.: | 709031-28-7 |
---|---|
Name: | 3-hydroxy- α-oxoadamantane-1-acetic acid |
Article Data: | 12 |
Molecular Structure: | |
Formula: | C12H16O4 |
Molecular Weight: | 224.257 |
Synonyms: | 3-Hydroxy-alpha-oxotricyclo[3.3.1.13,7]decane-1-acetic acid; |
EINECS: | 615-199-5 |
Density: | 1.477 g/cm3 |
Melting Point: | 164-165 °C |
Boiling Point: | 366.525 °C at 760 mmHg |
Flash Point: | 189.652 °C |
PSA: | 74.60000 |
LogP: | 0.97140 |
dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16.7h; Stage #2: With hydrogenchloride; sodium hydrogencarbonate In tetrahydrofuran; water for 5h; pH=7.4; Heating; | 99.53% |
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16h; pH=13.24; Stage #2: With hydrogenchloride; sodium hydrogencarbonate In tetrahydrofuran; water at 4 - 20℃; for 101.76h; pH=1.4 - 1.77; | 86.6% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic With sodium hydroxide; sodium hydrogencarbonate In water at 80℃; for 6h; pH=7.22; Stage #2: With hydrogenchloride In water pH=0.15; | 99% |
1-hydroxy-3-acetyladamantane
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With potassium permanganate; tetrabutylammomium bromide; potassium hydroxide In tert-butyl alcohol at 40℃; for 5h; Reagent/catalyst; | 91.8% |
With potassium permanganate; potassium hydroxide In tert-butyl alcohol at 40℃; for 5h; | 90% |
With potassium permanganate; potassium hydroxide In water; tert-butyl alcohol at 35 - 45℃; for 4.5h; | 86.6% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: 3-hydroxy-α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester With sodium hydroxide; water In tetrahydrofuran at 5 - 30℃; for 0.5h; pH=7 - 14; Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate pH=0.7; | 85% |
With sodium hydroxide In tetrahydrofuran; water at 30℃; pH=Ca. 7 - 14; Cooling with ice; |
1-acetyladamantane
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With potassium permanganate; potassium hydroxide In water at 90℃; | 84% |
With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide at 60 - 80℃; for 14.5h; | 47% |
Stage #1: 1-acetyladamantane With sodium hydroxide; potassium permanganate In water at 27 - 55℃; for 24.5 - 25.5h; Stage #2: In water Product distribution / selectivity; Acidic aqueous solution; |
1-acetyladamantane
A
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
B
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
Conditions | Yield |
---|---|
With potassium permanganate; potassium hydroxide In water at 50 - 80℃; for 12h; | A 80% B 0.8 g |
With sodium hydroxide; potassium permanganate In water; tert-butyl alcohol at 50 - 65℃; for 35h; Product distribution / selectivity; |
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid With sulfuric acid; nitric acid Stage #2: With hydrogenchloride In water | 76% |
Stage #1: oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid With sodium hydroxide; potassium permanganate In water at 20 - 60℃; for 11h; Stage #2: Acidic aqueous solution; | |
With sodium hydroxide; potassium permanganate In water at 55 - 60℃; for 11h; Product distribution / selectivity; |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With ω-transaminase |
1-Adamantanecarboxylic acid
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C 1.2: 2 h / 25 °C 2.1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere 3.1: potassium permanganate; potassium hydroxide / water / 90 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium permanganate; potassium hydroxide / water; tert-butyl alcohol / 8.5 h / 45 - 60 °C 2.1: thionyl chloride / 6 h / Reflux 3.1: sodium / Petroleum ether / 20 °C 3.2: 20 °C / Reflux 3.3: 6 h / Reflux 4.1: potassium permanganate; potassium hydroxide / tert-butyl alcohol / 5 h / 40 °C View Scheme |
1-Adamantanecarboxylic acid
A
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
B
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C 1.2: 2 h / 25 °C 2.1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere 3.1: potassium permanganate; potassium hydroxide / water / 12 h / 50 - 80 °C View Scheme |
What can I do for you?
Get Best Price
The cas register number of 2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid is 709031-28-7. It also can be called as 3-Hydroxy-alpha-oxotricyclo[3.3.1.13,7]decane-1-acetic acid and the Systematic name about this chemical is (3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)(oxo)acetic acid.
Physical properties about 2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid are: (1)ACD/LogP: -0.23; (2)ACD/LogD (pH 5.5): -3; (3)ACD/LogD (pH 7.4): -4; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 74.6 Å2; (12)Index of Refraction: 1.635; (13)Molar Refractivity: 54.384 cm3; (14)Molar Volume: 151.827 cm3; (15)Polarizability: 21.56x0-24cm3; (16)Surface Tension: 80.666 dyne/cm; (17)Enthalpy of Vaporization: 70.936 kJ/mol; (18)Boiling Point: 366.525 °C at 760 mmHg.
You can still convert the following datas into molecular structure:
SMILES: O=C(O)C(=O)C13CC2CC(CC(O)(C1)C2)C3
InChI: InChI=1/C12H16O4/c13-9(10(14)15)11-2-7-1-8(3-11)5-12(16,4-7)6-11/h7-8,16H,1-6H2,(H,14,15)
InChIKey: UDKIRRNUAXWHTO-UHFFFAOYAO
Std. InChI: InChI=1S/C12H16O4/c13-9(10(14)15)11-2-7-1-8(3-11)5-12(16,4-7)6-11/h7-8,16H,1-6H2,(H,14,15)
Std. InChIKey: UDKIRRNUAXWHTO-UHFFFAOYSA-N