Detail of "728-88-1"

CAS Number:
728-88-1
Name:
1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-
Superlist Name:
Tolperisone
Molecular Structure:
Formula:
C16H23 N O
Molecular Weight:
245.40
Synonyms:
Propiophenone,2,4'-dimethyl-3-piperidino- (7CI,8CI); (?à)-Tolperisone; 2,4'-Dimethyl-3-piperidinopropiophenone;Mideton; Mydeton; Mydetone; NSC 107321; Tolperisone; dl-Tolperisone
EINECS:
211-976-4
Safety:
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x. Details

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Mechanisms of depressant action of muscle relaxants on spinal reflexes: participation of membrane stabilizing action: Mechanisms of depressant action of muscle relaxants on spinal reflexes: participation of membrane stabilizing action. Ono, Hideki; Fukuda, Hideomi; Kudo, Yoshihisa (Fac. Pharm. Sci., Univ. Tokyo, Tokyo 113, Japan). J. Pharmacobio-Dyn., 7(3), 171-6 (English) 1984. CODEN: JOPHDQ. ISSN: 0386-846X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The participation of a local anesthetic action in the spinal reflex inhibition produced by mephenesin-type muscle relaxants was examd. by comparing the local anesthetic effects (in vitro), the depressant effects on muscle afferent discharges (in situ), and the depressant effects on spinal reflexes (in situ) of the drugs in rats. At doses producing depression of spinal reflexes, mephenesin [59-47-2], tolperisone [728-88-1], and lidocaine [137-58-6] reduced the frequency of afferent discharges from the muscle. The order of reducing afferent discharges of these drugs corresponded to that of their conduction-blocking activities in the isolated sciatic nerve of rats. Apparently, a membrane-stabilizing action participates in the spinal reflex inhibition produced by mephenesin-type muscle relaxants. Baclofen [1134-47-0] (nonmephenesin type) did not show any local anesthetic action.

A comparison of the effects of baclofen and some other muscle relaxants on a-rigidity in rats: A comparison of the effects of baclofen and some other muscle relaxants on a-rigidity in rats. Kawajiri, Shinichi; Kojima, Hiroshi; Akashi, Akira (Res. Inst., Daiichi Seiyaku Co. Ltd., Tokyo 134, Japan). Nippon Yakurigaku Zasshi, 83(3), 263-8 (Japanese) 1984. CODEN: NYKZAU. ISSN: 0015-5691. 439-14-5 and 58-25-3 are cas registry numbers. These chemicals are also mentioned in this article. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Baclofen [1134-47-0] and dantrolene [7261-97-4] intraduodenal (i.d.) administration suppressed sustained rigidity of forelimbs in rats with cerebral ischemia. ED50 of baclofen was 2.9 mg/kg and of dantrolene was 22 mg/kg. Baclofen, dantrolene, and diazepam [439-14-5] reduced the phase rigidity of the decerebrated animals with i.d. ED50 of 6.2, 140, and 1.4 mg/kg, resp. Both rigidities were insensitive to chlorodiazepoxide [58-25-3] and tolperisone [728-88-1]. Except for tolperisone, these drugs also produced muscle relaxation in intact rats and mice. The ED50 values of orally administered baclofen, dantrolene, diazepam, chlordiazepoxide, and tolperisone were 5.6, 15.0, 2.1, and 44.0 mg/kg, resp. in mice. .