Reference

Preparation and purification process of zonisamide from pure 1,2-benzisoxazole-3-methane-sulfonic acid sodium salt via chlorination and amination reactions

All Rights Reserved. Preparation and purification process of zonisamide from pure 1,2-benzisoxazole-3-methane-sulfonic acid sodium salt via chlorination and amination reactions. Mendelovici, Marioara; Shenkar, Natalia (Teva Pharmaceutical Industries Ltd.; Teva Pharmaceuticals Usa, Inc., Israel). PCT Int.Some commonly used reagents like 73101-65-2 and 73101-64-1 are used in this experiment. Appl. WO 2007016209 A2 8 Feb 2007, 24pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-US29121 28 Jul 2006. PRIORITY: US 2005-702994P 28 Jul 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The present invention provides anhyd. and monohydrate forms CP sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid, the sodium salt, and processes for prepg. the same via purifn. One of the embodiments of the present invention is directed to a process for prepg. zonisamide using the CP sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid via chlorination and amination reactions. .

Two crystalline forms of sodium 1,2-benzisoxazole-3-methanesulfonate, and processes for the preparation and use thereof in the synthesis of zonisamide

Two crystalline forms of sodium 1,2-benzisoxazole-3-methanesulfonate, and processes for the preparation and use thereof in the synthesis of zonisamide. Naddaka, Vladimir; Adin, Itai; Klopfer, Eyal; Arad, Oded; Kaspi, Joseph (Israel ). U.S. Pat. 73101-64-1 is the cas registry number of certain chemical which is used as reagents here. Appl. Publ. US 2006009644 A1 12 Jan 2006,20 pp. (English). (United States of America). CODEN: USXXCO. APPLICATION: US 2005-153403 16 Jun 2005. PRIORITY: US 2004-580360P 18 Jun 2004; US 2004-582086P 24 Jun 2004; US 2004-622009P 27 Oct 2004. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 45, 75 Disclosed is a process of prepg. 1,2-benzisoxazole-3-methanesulfonamide (zonisamide). Also disclosed is (1) a method of dehydrating sodium 1,2-benzisoxazole-3-methanesulfonate monohydrate (I.H2O; R = ONa), a compd. useful in the prepn. of zonisamide (I; R = NH2), as well as (2) the cryst. forms of the dehydrated salt, sodium 1,2-benzisoxazole-3-methanesulfonate (I; R = ONa). The hydrate I.H2O (R = ONa) was prepd. by sulfonylation of 3-(bromomethyl)-1,2-benzisoxazole with sodium sulfite. Compd. I.H2O (R = ONa) was dehydrated by azeotropic distn. from toluene or toluene/DMF to give two cryst. forms of the dehydrated I, as detd. by X-ray powder diffraction. Either form of dehydrated I (R = ONa) reacted with oxalyl chloride to give the corresponding sulfonyl chloride, which was treated in situ with ammonia to give zonisamide. .