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CAS No.: | 73821-97-3 |
---|---|
Name: | Boc-L-glutamic acid 5-cyclohexyl ester |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C16H27NO6 |
Molecular Weight: | 329.393 |
Synonyms: | N-tert-Butoxycarbonyl-L-glutamicacid g-cyclohexyl ester;N-tert-Butyloxycarbonyl-L-glutamic acid g-cyclohexyl ester;Boc-Glu(OcHex)-OH; |
Density: | 1.16 g/cm3 |
Melting Point: | 54-57 °C |
Boiling Point: | 502.6 °C at 760 mmHg |
Flash Point: | 257.8 °C |
Appearance: | white powder |
PSA: | 101.93000 |
LogP: | 3.01130 |
Conditions | Yield |
---|---|
With trimethyltin(IV) hydroxide In 1,2-dichloro-ethane for 10h; Heating; | 100% |
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
Conditions | Yield |
---|---|
With trimethyltin(IV) hydroxide In 1,2-dichloro-ethane for 12h; Heating; | 97% |
di-tert-butyl dicarbonate
γ-cyclohexyl L-glutamate
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethylguanidine In N,N-dimethyl-formamide for 12h; Ambient temperature; Yield given; |
L-glutamic acid
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2SO4 / diethyl ether / 2 h / 70 °C 2: 1,1,3,3-tetramethylguanidine / dimethylformamide / 12 h / Ambient temperature View Scheme |
cyclohexanol
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2SO4 / diethyl ether / 2 h / 70 °C 2: 1,1,3,3-tetramethylguanidine / dimethylformamide / 12 h / Ambient temperature View Scheme |
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
L-glutamic acid
Conditions | Yield |
---|---|
With phenylthiotrimethylsilane; pertrimethylsilylated Nafion; 3-methyl-phenol; trifluoroacetic acid for 3h; | 100% |
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
(S)-2-azido-3-hydroxypropionic acid methyl ester
methyl (2S,2'S)-2-azido-3-(N-Boc-ω-cyclohexyl-glutamyloxy)propionate
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In dichloromethane at 0 - 20℃; | 99% |
Stage #1: N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #2: (S)-2-azido-3-hydroxypropionic acid methyl ester In dichloromethane at 0 - 20℃; Inert atmosphere; | 99% |
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
Boc-Glu(OcHex)-Gln-Glu(OcHex)-Lys(Z)-Gln-Ala-Lys(Z)-OBzl
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 4℃; for 8h; | 96% |
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
Boc-Glu(OcHex)-Tfeg-Tfeg-Lys(ClZ)-OTce
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; Acylation; | 96% |
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 6h; | 96% |
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IUPAC Name: 5-Cyclohexyloxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoicacid
Following is the structure of L-Glutamic acid,N-[(1,1-dimethylethoxy)carbonyl]-, 5-cyclohexyl ester (CAS NO.73821-97-3):
Empirical Formula: C16H27NO6
Molecular Weight: 329.3887
Index of Refraction: 1.497
Molar Refractivity: 83.06 cm3
Molar Volume: 283.4 cm3
Density: 1.16 g/cm3
Flash Point: 257.8 °C
Melting point: 54-57 °C
Storage temp.: 2-8 °C
Surface Tension: 45.2 dyne/cm
Enthalpy of Vaporization: 84.48 kJ/mol
Boiling Point: 502.6 °C at 760 mmHg
Vapour Pressure of L-Glutamic acid,N-[(1,1-dimethylethoxy)carbonyl]-, 5-cyclohexyl ester (CAS NO.73821-97-3): 1.82E-11 mmHg at 25 °C
Product Categories of L-Glutamic acid,N-[(1,1-dimethylethoxy)carbonyl]-, 5-cyclohexyl ester (CAS NO.73821-97-3): Amino Acid Derivatives; Amino Acids; Glutamic acid [Glu, E]; Boc-Amino Acids and Derivative
Canonical SMILES: CC(C)(C)OC(=O)NC(CCC(=O)OC1CCCCC1)C(=O)O
InChI: InChI=1S/C16H27NO6/c1-16(2,3)23-15(21)17-12(14(19)20)9-10-13(18)22-11-7-5-4-6-8-11/h11-12H,4-10H2,1-3H3,(H,17,21)(H,19,20)
InChIKey: FDNMLANBNJDIRG-UHFFFAOYSA-N
WGK Germany: 3
L-Glutamic acid,N-[(1,1-dimethylethoxy)carbonyl]-, 5-cyclohexyl ester , its cas register number 73821-97-3. It also can be called Boc-Glu(Ochx)-OH ; Boc-L-glutamic acid 5-cyclohexyl ester ; and (2S)-5-(Cyclohexyloxy)-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-5-oxopentanoic acid .