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CAS No.: | 7487-94-7 |
---|---|
Name: | Mercury(II) chloride |
Molecular Structure: | |
Formula: | Cl2Hg |
Molecular Weight: | 271.496 |
Synonyms: | Bichloride of mercury;Chlorid rtutnaty; |
EINECS: | 231-299-8 |
Density: | 5.44 |
Melting Point: | 277 °C(lit.) |
Boiling Point: | 302 °C |
Flash Point: | 302°C |
Solubility: | soluble in water |
Appearance: | white crystalline powder |
Hazard Symbols: | T+; N |
Risk Codes: | 28-34-48/24/25-50/53 |
Safety: | 36/37/39-45-60-61 |
Transport Information: | UN 1624 6.1/PG 2 |
PSA: | 0.00000 |
LogP: | 1.37650 |
The Mercury(II) chloride, with the CAS registry number 7487-94-7 and EINECS registry number 231-299-8, is a kind of white crystals. And the molecular formula of this chemical is Cl2Hg. It is sensitive to moisture, and will decompose by sunlight. What's more, it is soluble in water, and can be stored at room temperature.
The physical properties of Mercury(II) chloride are as following: (1)ACD/LogP: 0.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0; (4)ACD/LogD (pH 7.4): 0; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)#H bond acceptors: 0; (8)#H bond donors: 0; (9)#Freely Rotating Bonds: 0; (10)Polar Surface Area: 0 Å2; (11)Enthalpy of Vaporization: 16.15 kJ/mol; (12)Boiling Point: °C at 760 mmHg; (13)Vapour Pressure: 33900 mmHg at 25°C.
Preparation of Mercury(II) chloride: It can be obtained by the action of chlorine on mercury or mercury(I) chloride, by the addition of hydrochloric acid to a hot, concentrated solution of mercury(I) compounds such as the nitrate:
HgNO3 + 2 HCl → HgCl2 + H2O + NO2
Uses of Mercury(II) chloride: It was used in photography, preservation. It was also used in medicine, but because is highly toxic, it is no longer used for medicinal purposes. It is often used as a chemical reagent. What's more, the main application of mercuric chloride is as a catalyst for the conversion of acetylene to vinyl chloride, the precursor to polyvinylchloride:
C2H2 + HCl → CH2=CHCl
You should be cautious while dealing with this chemical. It is toxic to aquatic organisms, and may cause long-term adverse effects in the aquatic environment. It also has danger of serious damage to health by prolonged exposure in contact with skin and if swallowed. What's more, it may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of accident or if you feel unwell, seek medical advice immediately (show label where possible); This material and/or its container must be disposed of as hazardous waste; Avoid release to the environment. Refer to special instructions safety data sheet.
You can still convert the following datas into molecular structure:
(1)SMILES: Cl[Hg]Cl
(2)InChI: InChI=1/2ClH.Hg/h2*1H;/q;;+2/p-2
(3)InChIKey: LWJROJCJINYWOX-NUQVWONBAW
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 2710ug/kg (2.71mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 423, 1932. | |
dog | LDLo | oral | 10mg/kg (10mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
frog | LD50 | intramuscular | 7579ug/kg (7.579mg/kg) | Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. Vol. 85, Pg. 253, 1986. | |
frog | LD50 | intramuscular | 7579ug/kg (7.579mg/kg) | Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. Vol. 85, Pg. 253, 1986. | |
frog | LD50 | intramuscular | 7579ug/kg (7.579mg/kg) | Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. Vol. 85, Pg. 253, 1986. | |
frog | LDLo | oral | 2424mg/kg (2424mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
frog | LDLo | subcutaneous | 2gm/kg (2000mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
guinea pig | LDLo | intraperitoneal | 345mg/kg (345mg/kg) | Archives of Environmental Health. Vol. 11, Pg. 201, 1965. | |
guinea pig | LDLo | skin | 345mg/kg (345mg/kg) | Archives of Environmental Health. Vol. 11, Pg. 201, 1965. | |
human | LDLo | oral | 29mg/kg (29mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE GASTROINTESTINAL: NAUSEA OR VOMITING | New England Journal of Medicine. Vol. 244, Pg. 459, 1951. |
man | LDLo | oral | 14286ug/kg (14.286mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED GASTROINTESTINAL: NAUSEA OR VOMITING | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 2383, 1999. |
man | LDLo | oral | 86mg/kg (86mg/kg) | VASCULAR: CHANGE IN PLASMA OR BLOOD VALUME GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: NECROTIC GHANGES | Journal of Toxicology, Clinical Toxicology. Vol. 26, Pg. 189, 1988. |
man | LDLo | oral | 143mg/kg (143mg/kg) | BEHAVIORAL: EXCITEMENT KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT | Igaku to Seibutsugaku. Medicine and Biology. Vol. 2, Pg. 48, 1942. |
man | LDLo | unreported | 7253ug/kg (7.253mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TDLo | oral | 21mg/kg (21mg/kg) | GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Clinical Toxicology. Vol. 11, Pg. 309, 1977. |
man | TDLo | oral | 29mg/kg (29mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | Medical Journal of Australia. Vol. 2, Pg. 125, 1978. |
man | TDLo | oral | 57mg/kg (57mg/kg) | GASTROINTESTINAL: GASTRITIS LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Japanese Journal of Toxicology. Vol. 8, Pg. 157, 1995. |
mouse | LCLo | inhalation | 300mg/m3/10M (300mg/m3) | National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. No.9-4-1-9, Pg. 1943, | |
mouse | LD50 | intraperitoneal | 3900ug/kg (3.9mg/kg) | Pharmaceutical Chemistry Journal Vol. 25, Pg. 891, 1991. | |
mouse | LD50 | intravenous | 4992ug/kg (4.992mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 21, Pg. 364, 1948. | |
mouse | LD50 | oral | 6mg/kg (6mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(1), Pg. 76, 1986. |
mouse | LD50 | subcutaneous | 4500ug/kg (4.5mg/kg) | Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 34, Pg. 193, 1979. | |
pigeon | LDLo | oral | 2200mg/kg (2200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1389, 1935. | |
pigeon | LDLo | subcutaneous | 1100mg/kg (1100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1389, 1935. | |
quail | LD50 | intramuscular | 34mg/kg (34mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA | Journal of Toxicology and Environmental Health. Vol. 20, Pg. 105, 1987. |
quail | LD50 | oral | 36mg/kg (36mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA | Journal of Toxicology and Environmental Health. Vol. 20, Pg. 105, 1987. |
rabbit | LD50 | intramuscular | 7300ug/kg (7.3mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 119, 1946. | |
rabbit | LDLo | intravenous | 2mg/kg (2mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: MUSCLE WEAKNESS | Journal of Pharmacology and Experimental Therapeutics. Vol. 35, Pg. 343, 1929. |
rabbit | LDLo | oral | 20mg/kg (20mg/kg) | "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931. | |
rabbit | LDLo | subcutaneous | 10mg/kg (10mg/kg) | Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975. | |
rat | LD50 | intraperitoneal | 3210ug/kg (3.21mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Proceedings of the European Society for the Study of Drug Toxicity. Vol. 12, Pg. 247, 1971. |
rat | LD50 | intravenous | 1272ug/kg (1.272mg/kg) | Archives of Toxicology. Vol. 58, Pg. 243, 1986. | |
rat | LD50 | oral | 1mg/kg (1mg/kg) | Pesticide Manual. Vol. 9, Pg. 550, 1991. | |
rat | LD50 | skin | 41mg/kg (41mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(7), Pg. 27, 1981. | |
rat | LD50 | subcutaneous | 14mg/kg (14mg/kg) | Japanese Journal of Experimental Medicine. Vol. 39, Pg. 47, 1969. | |
women | TDLo | oral | 18mg/kg (18mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED BLOOD: OTHER CHANGES | Human & Experimental Toxicology. Vol. 11, Pg. 53, 1992. |
women | TDLo | oral | 50mg/kg (50mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | American Journal of Obstetrics and Gynecology. Vol. 80, Pg. 145, 1960. |