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77-10-1

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Basic Information
CAS No.: 77-10-1
Name: PHENCYCLIDINE
Article Data: 18
Molecular Structure:
Molecular Structure of 77-10-1 (PHENCYCLIDINE)
Formula: C17H25 N
Molecular Weight: 243.392
Synonyms: 1-(1-Phenylcyclohexyl)piperidine;Angel dust; Cl 395; HOG; PCP; PCP (anesthetic); Phencyclidine
Density: 0.9762 (rough estimate)
Melting Point: 46.5℃
Boiling Point: bp1.0 135-137°
Flash Point: 11 °C
Hazard Symbols: F,T
Risk Codes: 23/24/25-39/23/24/25-11-61
Safety: Poison by intraperitoneal route. Experimental reproductive effects. Caution: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). The ethylamine, pyrrolidine and thiophene analogs are listed as hallucinogens, Title 21 Part 1308.11. When heated to decomposition it emits toxic fumes of NOx.
PSA: 3.24000
LogP: 4.26980
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Chemistry

MF: C17H25N
MW: 243.39
Appearance: solid
Density: 1.013 g/cm3 
Flash Point: 144.5 °C 
Storage temp: −20°C
Index of Refraction: 1.551 
Enthalpy of Vaporization: 58.35 kJ/mol 
Boiling Point: 340 °C at 760 mmHg
Vapour Pressure: 8.86E-05 mmHg at 25°C 
Stability: Stable. Combustible. Incompatible withstrong oxidizing agents
IUPAC Name: 1-(1-phenylcyclohexyl)piperidine
Synonyms: PCP ; Phencyclidine ; 1-(1-Phenylcyclohexyl)piperidine ; Pcp (phencyclidine) ; Phencyclidine (pcp) ; Phencylidine ; Piperidine, 1-(1-phenylcyclohexyl)- ; 1-(1-Phenylcyclohexyl)piperidine solution, PCP solution
Following is the molecular structure of Phencylidine (77-10-1):

History

Phencylidine (77-10-1) was first synthesized in 1926, and later tested after World War II as a surgical anesthetic. Because of its adverse side effects, such as hallucinations, mania, delirium, and disorientation, it was shelved until the 1950s. In 1953, it was patented by Parke-Davis and named Sernyl (referring to serenity), but was withdrawn from the market two years later because of side-effects. It was renamed Sernylan in 1967, and marketed as a veterinary anesthetic, but again discontinued. Its side effects and long half-life in the human body made it unsuitable for medical applications.

Toxicity Data With Reference

1.    

ipr-mus LD50:2800 µg/kg

    TOLED5    Toxicology Letters. 12 (1982),171.

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Caution: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). The ethylamine, pyrrolidine and thiophene analogs are listed as hallucinogens, Title 21 Part 1308.11. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Phencylidine (77-10-1):
Hazard Codes: F,T
F: Highly Flammable T: Toxic
Risk Statements: 23/24/25-39/23/24/25
23/24/25: Toxic by inhalation, in contact with skin and if swallowed 
39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed  
Safety Statements: 36/37-45
36/37: Wear suitable protective clothing and gloves
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)   
RIDADR: 2811
HazardClass: 6.1(a)
PackingGroup: I
 

Specification

Phencyclidine (77-10-1)(a complex clip of the chemical name phenylcyclohexylpiperidine, commonly initialised as PCP), also known as angel dust and other street names, is a recreational, dissociative drug formerly used as an anaesthetic agent, exhibiting hallucinogenic and neurotoxic effects. Developed in 1926, it was first patented in 1952 by the Parke-Davis pharmaceutical company and marketed under the brand name Sernyl. In chemical structure, PCP is an arylcyclohexylamine derivative, and, in pharmacology, it is a member of the family of dissociative anesthetics. PCP works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA receptor. Other NMDA receptor antagonists include ketamine, tiletamine, and dextromethorphan. Although the primary psychoactive effects of the drug lasts for a few hours, the total elimination rate from the body typically extends 8 days or longer.