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CAS No.: | 3867-15-0 |
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Name: | 1-piperidinocyclohexanecarbonitrile |
Article Data: | 24 |
Molecular Structure: | |
Formula: | C12H20 N2 |
Molecular Weight: | 192.304 |
Synonyms: | Cyclohexanecarbonitrile,1-piperidino- (6CI,7CI,8CI); 1-(1-Cyanocyclohexyl)piperidine;1-Cyano-1-(1-piperidinyl)cyclohexane; 1-Cyano-1-piperidinocyclohexane;1-Piperidino-1-cyanocyclohexane; 1-Piperidino-1-cyclohexanecarbonitrile;1-Piperidinocyclohexanecarbonitrile; NSC 97072; PCC |
Density: | 1.01g/cm3 |
Boiling Point: | 309.5°Cat760mmHg |
Flash Point: | 126.9°C |
Safety: | Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and CN−. See also NITRILES. |
PSA: | 27.03000 |
LogP: | 2.63668 |
trimethylsilyl cyanide
C6H10C5H10N(1+)*ClO4(1-)=(C6H10C5H10N)(ClO4)
1-piperidinocyclohexylcarbonitrile
Conditions | Yield |
---|---|
With Co(II) complex supported on mesoporous SBA-15 at 40℃; for 3h; Strecker-type reaction; | 95% |
With Co(II) complex supported on mesoporous SBA-15 at 40℃; for 3h; Strecker type reaction; Sealed tube; | 95% |
Conditions | Yield |
---|---|
In neat (no solvent) at 60 - 70℃; | 88% |
piperidine
sodium cyanide
cyclohexanone
1-piperidinocyclohexylcarbonitrile
Conditions | Yield |
---|---|
With sodium hydrogensulfite at 20℃; | 82.1% |
piperidine
cyclohexanone
2-hydroxy-2-methylpropanenitrile
1-piperidinocyclohexylcarbonitrile
Conditions | Yield |
---|---|
With magnesium sulfate In N,N-dimethyl acetamide at 45℃; for 48h; | 80% |
piperidine
sodium cyanide
cyclohexanone
1-piperidinocyclohexylcarbonitrile
Conditions | Yield |
---|---|
With hydrogenchloride | 77% |
With hydrogenchloride | |
With hydrogenchloride | |
pH=5; Strecker type reaction; | |
With hydrogenchloride |
Conditions | Yield |
---|---|
With sodium hydrogensulfite | 77% |
With sodium hydrogensulfite | |
With sodium hydrogen sulfite | |
With sodium hydrogen sulfite |
potassium cyanide
piperidine hydrochloride
cyclohexanone
1-piperidinocyclohexylcarbonitrile
Conditions | Yield |
---|---|
With ethanol |
piperidine
ethanol
water
potassium cyanide
cyclohexanone
1-piperidinocyclohexylcarbonitrile
Conditions | Yield |
---|---|
beim Behandeln des Hydrochlorids; |
piperidine
trimethylsilyl cyanide
cyclohexanone
1-piperidinocyclohexylcarbonitrile
Conditions | Yield |
---|---|
With zinc(II) iodide In methanol; diethyl ether at 80℃; for 8h; Strecker reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / water / 20 - 25 °C 2: neat (no solvent) / 60 - 70 °C View Scheme |
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1. | orl-mus LD50:133 mg/kg | JPPMAB Journal of Pharmacy and Pharmacology. 28 (1976),713. | ||
2. | ipr-mus LD50:30 mg/kg | JATOD3 Journal of Analytical Toxicology. 4 (1980),119. | ||
3. | ivn-mus LD50:18 mg/kg | CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03387 . |