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Basic Information
CAS No.: 77-37-2
Name: procyclidine
Article Data: 5
Molecular Structure:
Molecular Structure of 77-37-2 (procyclidine)
Formula: C19H29 N O
Molecular Weight: 287.445
Synonyms: (?à)-Procyclidine;1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol;1-Cyclohexyl-1-phenyl-3-pyrrolidinopropan-1-ol; Elorine; Kemadrine; Lergine;NSC 169103; Procyclidine; Tricoloid; Tricyclamol; Vagosin; a-Cyclohexyl-a-phenyl-1-pyrrolidinepropanol
EINECS: 201-023-0
Density: 1.057 g/cm3
Melting Point: 85.5-86.5°
Boiling Point: 433.5 °C at 760 mmHg
Flash Point: 205.7 °C
Solubility: 1.055mg/L(22.5 oC)
Safety: A poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
PSA: 23.47000
LogP: 3.87830
Synthetic route
94-39-3

1-phenyl-3-(pyrrolidin-1-yl)propan-1-one

931-50-0

cyclohexylmagnesium bromide

77-37-2

procyclidine

6072-22-6

Pyrrinol

77-37-2

procyclidine

Conditions
ConditionsYield
With acetic acid; platinum Hydrogenation;
With acetic acid; platinum Hydrogenation;
6317-35-7

ethyl 3-tetrahydro-1H-1-pyrrolilpropanoate

77-37-2

procyclidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether
2: platinum; aqueous acetic acid / Hydrogenation
View Scheme

phenylmagnesium bromide

77-37-2

procyclidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether
2: platinum; aqueous acetic acid / Hydrogenation
View Scheme
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

77-37-2

procyclidine

3,4,5-trimethoxy-benzoic acid-(1-cyclohexyl-1-phenyl-3-pyrrolidino-propyl ester)

Conditions
ConditionsYield
With benzene
75-03-6

ethyl iodide

77-37-2

procyclidine

32381-63-8, 32476-62-3, 112841-59-5

(+/-)-1-ethyl-1-(3-cyclohexyl-3-hydroxy-3-phenyl-propyl)-pyrrolidinium; iodide

Conditions
ConditionsYield
With ethanol
77-37-2

procyclidine

74-88-4

methyl iodide

6856-40-2

(+/-)-1-(3-cyclohexyl-3-hydroxy-3-phenyl-propyl)-1-methyl-pyrrolidinium; iodide

Conditions
ConditionsYield
With acetone
77-37-2

procyclidine

102043-66-3

(S)-Procyclidine

77-37-2

procyclidine

102727-66-2

(R)-Procyclidine

77-37-2

procyclidine

32381-62-7

(S)-Tricylamol iodide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: acetone / 3 h / Ambient temperature
View Scheme
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Chemistry

Chemical Name: Procyclidine
IUPAC NAME: 1-Cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
CAS No.: 77-37-2
EINECS: 201-023-0
Molecular Formula: C19H29NO
Molecular Weight: 287.44 g/mol
Density: 1.057 g/cm3
Flash Point: 205.7 °C
Boiling Point: 433.5 °C at 760 mmHg
Following is the structure of 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol (CAS No.77-37-2):


The chemical synonymous of 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol (CAS No.77-37-2) are 1-Cyclohexyl-1-Phenyl-3-Pyrrolidin-1-Ylpropan-1-Ol ; Procyclidine ; Tricyclamol ; Kemadrine ; Vagosin ; Α-Cyclohexyl-Α-Phenyl-1-Pyrrolidine-1-Propanol

Toxicity Data With Reference

1.    

ipr-mus LD50:131 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,291.
2.    

ivn-mus LD50:60 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,291.

Safety Profile

A poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.