Reference

Characteristics of volumetric regulation under the effect of dehydrocholic acid

Characteristics of volumetric regulation under the effect of dehydrocholic acid. Yakovlev, V. E. (Chernivets. Med. Inst., Chernovitsy, USSR). Fiziol. Zh. (Kiev), 23(1), 78-82 (Ukrainian) 1977. CODEN: FZUKAM. 9088-07-7 and 7440-23-5 are cas registry numbers of chemicals which are used as reagents here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In rats, dehydrocholic acid (I) [81-23-2] (25 mg/100 g, orally) increased Na excretion. Long-term administration induced diuresis. I therapy also increased the extracellular space and at the same time increased the urinary excretion of Na and K. In expts. with water and salt loading after long-term I administration, there was a greater diuresis and electrolyte excretion than in untreated controls. The I action is due to the increased formation or activation of the natriuretic factor [9088-07-7] in the liver. .

Liver microvascular flow in rats: quantitation by laser Doppler flowmetric technique and effects of sodium dehydrocholate

Liver microvascular flow in rats: quantitation by laser Doppler flowmetric technique and effects of sodium dehydrocholate. Koo, Anthony (Fac. Med., Chin. Univ. Hong Kong, Shatin, Hong Kong). J. Gastroenterol. Hepatol., 1(5), 347-58 (English) 1986. CODEN: JGHEEO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 9 An in vivo, in situ liver prepn. in anesthetized rats was devised for the simultaneous measurements of hepatic microvascular flow and bile flow. The microvascular flow on the surface of the liver was continuously recorded by laser Doppler flowmetric technique, while bile flow was quantitated by connecting the bile duct cannula to a drop counter. Dehydrocholate [81-23-2], infused (0.2 mL in 2-5 min) either via a cannula in the splenic artery and via a cannula in the superior mesenteric vein; increased the liver microvascular flow and bile flow. A cross-plot between the hyperemic and hypercholeretic responses corresponding to the same dose of dehydrocholate revealed a pos. correlation between the dehydrocholate-induced hypercholeresis and hyperemia. Furthermore, the increase of microvascular flow occurred earlier than the hypercholeretic response. Thus, an increase of plasma blood flow appears to be essential for the development of hypercholeresis induced by dehydrocholate.