Reference

Pharmaceutical composition for use in treatment of diabetes

Pharmaceutical composition for use in treatment of diabetes. Ikeda, Hitoshi; Sohda, Takashi; Odaka, Hiroyuki (Takeda Chemical Industries, Ltd., Japan). Eur. Pat. Appl. EP 749751 A2 27 Dec 1996, 16 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE.There are some reagents with their cas registry numbers 111-02-4 and 83480-29-9 are used in this study. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: A61K031-41. ICI: A61K031-41, A61K031-00. APPLICATION: EP 1996-304570 20 Jun 1996. PRIORITY: JP 1995-153500 20 Jun 1995. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Pharmaceutical compn. which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes. As an example, rats given pioglitazone hydrochloride (oral, 3 mg/kg/day) and/or glibenclamide (an insulin secretion enhancer-- oral 3 mg/kg/day) for 7 days. The increase of blood sugar following glucose loading was remarkably inhibited by the combined administration of pioglitazone and glibenclamide as compared with the administration of the drug alone. .

a-Glucosidase inhibitor

a-Glucosidase inhibitor. Toyota, Takayoshi (Sch. Med.Chemicals with cas numbers 83480-29-9 and 9001-42-7 also play role., Tohoku Univ., Sendai 980-77, Japan). Sogo Rinsho, 45(12), 2760-2764 (Japanese) 1996 Nagai Shoten. CODEN: SORIAX. ISSN: 0371-1900. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review with 8 refs., on the structure and function of antidiabetic a-glucosidase inhibitors such as Glucobay (acarbose) and Basen (voglibose), and their combined treatment with sulfonylurea. .