Reference

Manufacture of 4-[

Manufacture of 4-[.gamma.-(triethylsilyl)propylamino] quinoline. Lukevics, E.; Lapina, T.; Kruzmetra, L.; Zile, A. (Institute of Organic Synthesis, Academy of Sciences, Latvian S.S.R., USSR). U.S.S.R. SU 492166 5 Dec 1976 From: Otkrytiya, Izobret., Prom. Obraztsy, Tovarnye Znaki 1976, 53(45), 225. (Russian). (Union of Soviet Socialist Republics). CODEN: URXXAF. CLASS: IC: C07D215-42. APPLICATION: SU 73-1976822 14 Dec 1973. DOCUMENT TYPE: Patent CA Section: 29 (Organometallic and Organometalloidal Compounds) Section cross-reference(s): 27 The title compds., I (R1 = H, Me; R2 = H, Cl), or I.HCl, with fungistatic and bacteriostatic activity, were prepd.Except for chemicals metioned above, 86-98-6 and 62619-95-8 are also used. by treating II with Et3Si(CH2)3NH2 in diglyme. .

Synthesis of 4-[(4-substituted aryl)amino]-7-chloroquinolines and their antimalarial & antifilarial activities

Synthesis of 4-[(4-substituted aryl)amino]-7-chloroquinolines and their antimalarial & antifilarial activities. Chauhan, P. M. S.; Sharma, S.; Bhakuni, D. S. (Med. Chem. Div., Cent. Drug Res. Inst., Lucknow 226 001, India). Indian J. Chem., Sect. B, 25B(8), 828-31 (English) 1986. CODEN: IJSBDB. ISSN: 0376-4699. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 (Arylamino)chloroquinolines I (R = NH2, NCS, NHCO2Et) and II (R1 = COR2; R2 = H, N-phenylpiperizino, N-methylpiperizino, morpholino; R1 = NHAc, NH2, NCS, NHCSR3; R3 = 4-phenylpiperizino, 4-methylpiperizino, morpholino) were prepd. by condensation of 4,7-dichloroquinoline with anilines. I and II were tested for antifilarial and antimalarial activities against Litomosoides carinii in cotton rats and P. berghei in mice, resp., and were inactive.Except for chemicals metioned above, 108199-12-8 and 86-98-6 are also used. .