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| CAS No.: | 863513-91-1 |
|---|---|
| Name: | GRT6005 |
| Article Data: | 9 |
| Molecular Structure: | |
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| Formula: | C24H27FN2O |
| Molecular Weight: | 378.49 |
| Synonyms: | Cebranopadol;Cebranopadol (USAN/INN);(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine;(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine; |
| Density: | 1.23±0.1 g/cm3(Predicted) |
| Boiling Point: | 547.5±50.0 °C(Predicted) |
| PSA: | 28.26000 |
| LogP: | 5.10610 |
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- 911112-05-55-Iodo-3-(trifluoromethyl)-2-pyridinamine
- 886364-50-71-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone
- 65619-20-7
4-dimethylamino-4-phenylcyclohexanone
- 101349-12-6
2-(5-fluoro-1H-indol-3-yl)ethanol
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
| Conditions | Yield |
|---|---|
| With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 22 - 40℃; for 65h; Inert atmosphere; | 91% |
| Stage #1: 4-dimethylamino-4-phenylcyclohexanone; 2-(5-fluoro-1H-indol-3-yl)ethanol With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20 - 45℃; for 65h; Inert atmosphere; Stage #2: With sodium hydroxide In dichloromethane; water at 21 - 22℃; | 91% |
| With sulfuric acid In acetic acid at 45 - 60℃; | 60% |
- 4746-97-8
cyclohexanedione monoethylene ketal
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: hydrogenchloride / water; methanol / 0 - 20 °C 2.1: tetrahydrofuran / 0 - 20 °C 2.2: 0 - 20 °C 3.1: water; hydrogenchloride / diethyl ether 4.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 h / 20 °C / Inert atmosphere View Scheme |
- 65619-92-3
8-(dimethylamino)-1,4-dioxaspiro-[4.5]-decane-8-carbonitrile
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 0 - 20 °C 1.2: 0 - 20 °C 2.1: water; hydrogenchloride / diethyl ether 3.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 h / 20 °C / Inert atmosphere View Scheme |
- 65619-19-4
4-dimethylamino-4-phenylcyclohexanone, ethylene ketal hydrochloride
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: water; hydrogenchloride / diethyl ether 2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 h / 20 °C / Inert atmosphere View Scheme |
- 50-00-0
formaldehyd
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
| Conditions | Yield |
|---|---|
| With formic acid In water at 70℃; for 16h; Eschweiler-Clark Amine Methylation; | 280 mg |
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
- 1443039-98-2
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In tetrahydrofuran; water; acetone at 20℃; for 120h; Concentration; Solvent; Time; | |
| With hydrogenchloride In tetrahydrofuran; water; acetone at 20℃; for 24h; |
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
- 1443050-72-3
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine sulfate
| Conditions | Yield |
|---|---|
| With sulfuric acid In tetrahydrofuran; water; acetone at 20℃; for 24h; Solvent; Time; Temperature; Reagent/catalyst; |
- 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine
- 77-92-9
citric acid
| Conditions | Yield |
|---|---|
| In ethanol at 5℃; Heating; | 640 mg |
