Reference

Evidence for isosorbide dinitrate (ISDN) promoting effect on prostacyclin release by the lung and prostacyclin implication in ISDN-induced inhibition of platelet aggregation in humans

Evidence for isosorbide dinitrate (ISDN) promoting effect on prostacyclin release by the lung and prostacyclin implication in ISDN-induced inhibition of platelet aggregation in humans. Rolland, Pierre H.; Bory, Michel; Leca, Francois; Sainsous, Joel; Gueydon, Elizabeth; Juhan, Irene; Serradimigni, Andre; Cano, Jean Paul (Dep. Pharmacol. Cell. Cardiovasc., Fac. Pharm., Marseille 13385/5, Fr.). Prostaglandins, Leukotrienes Med., 16(3), 333-46 (English) 1984. CODEN: PLMEDD. ISSN: 0262-1746. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Isosorbide dinitrate (ISDN) [87-33-2] administered into the right atria increased aortic plasma levels of prostacyclin [35121-78-9] and PGF2a [551-11-1], decreased plasma PGE2 [363-24-6], decreased PGE2 formation by blood platelets, and lowered the platelet aggregation response to ADP. In contrast, TXB2 [54397-85-2]-related features were little affected by ISDN. In coronary sinus blood, the effects of ISDN were diminished or abolished relative to those in aortic blood. This supports the view that ISDN promotes release of prostaglandin and PGF2a from the lung but inhibits PGE2 prodn. The effects of ISDN on prostanoids are discussed with regard to its potential for relieving myocardial ischemia.

The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans

The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans. Fitzgerald, Desmond J.; Roy, Louis; Robertson, Rose Marie; FitzGerald, Garret A. (Div. Clin. Pharmacol., Vanderbilt Univ., Nashville, TN 37232, USA). Circulation, 70(2), 297-302 (English) 1984. CODEN: CIRCAZ. ISSN: 0009-7322. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Administration of short-acting (nitroglycerin [55-63-0]) and long-acting (isosorbide dinitrate [87-33-2]) org. nitrates to healthy subjects and angina pectoris patients, resp., had no effect on excretion of urinary 2,3-dinor-6-ketoprostaglandin F1a [64700-71-6], a noninvasive index of prostacyclin [35121-78-9] formation. Nevertheless, nitroglycerin exerted definite hemodynamic responses in all subjects and inhibited platelet aggregation in at least one. Apparently, the biol. effects of the org. nitrates are not mediated via stimulation of prostacyclin formation. TXB2 [54397-85-2] formation was also unaffected by nitroglycerin.