Detail of "88965-00-8"

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Process for preparation of zolpidem via treatment of 3-(dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyri dine with alkyl halide, alkali metal cyanide, and base

All Rights Reserved. Process for preparation of zolpidem via treatment of 3-(dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyri dine with alkyl halide, alkali metal cyanide, and base. Padi, Pratap Reddy; Bollikonda, Satyanarayana; Jasty, Ananda Mohan; Tamma, Ranga Reddy; Mohanarangam, Saravanan; Yasareni, Sumalatha; Rupakala, Gowri Shanker; Debasish, Ghosh (India ). 74-88-4 and 88965-00-8 are also occured in this study. U.S. Pat. Appl. Publ. US 2007027180 A1 1 Feb 2007,13pp. (English). (United States of America). CODEN: USXXCO. INCL: 514303000; 546117000. APPLICATION: US 2006-532959 19 Sep 2006. PRIORITY: IN 2005-CH1318 19 Sep 2005; US 2006-788821P 3 Apr 2006. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 45 A process for prepn. of zolpidem comprises treatment of 3-(dimethylaminomethyl)-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyri dine successively with alkyl halide, alkali metal cyanide, and base to form 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic acid. The title process reduces levels of zolpidic acid, zolpidem amide, zolpidem methylamine, and zolpidem acetamide impurities. .