Reference

Eugenol and prostaglandin biosynthesis

Eugenol and prostaglandin biosynthesis. Rasheed, Azmat; Laekeman, Gert; Totte, Jozef; Vlietinck, Arnold J.; Herman, Arnold G. (Univ. Antwerp, Wilrijk 2610, Belg.). N. Engl. J. Med., 310(1), 50-1 (English) 1984. CODEN: NEJMAG. ISSN: 0028-4793. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Arachidonic acid [506-32-1]-induced platelet aggregation was inhibited by nutmeg oil (IC50 1.3-1.6 ′ 10-5 g/mL). Several components of nutmeg oil were also tested, and their IC50 values in decreasing potency were: eugenol [97-53-0], 4.5 ′ 10-8 g/mL, isoeugenol [97-54-1], 1 ′ 10-7 g/mL; safrole [94-59-7], 1.7 ′ 10-5 g/mL; myristicin [607-91-0]; elemicin [487-11-6], 8.5 ′ 105 g/mL, and limonene [138-86-3], 8.9 ′ 10-5 g/mL. The IC50 of indomethacin tested in the same model was 2 ′ 10-7 g/mL. In a 2nd test, thromboxane B2 [54397-85-2] formation from arachidonic acid by washed platelets was inhibited by nutmeg oil and eugenol. Since eugenol appears to be the most potent ingredient of nutmeg oil and in view of the reported side effects of the complete nutmeg oil, it is suggested that eugenol may be useful therapeutically (e.g. as an antidiarrheal or antiinflammatory agent).

Studies of Artemisia dracunculus L

Studies of Artemisia dracunculus L.s.l. (tarragon). Albasini, A.; Bianchi, A.; Melegari, M.; Vampa, G.; Pecorari, P.; Rinaldi, M. (Ist. Chim. Farm. Tossicol., Univ. 80-56-8 and 562-74-3 are cas registry numbers of chemicals which are used as reagents here. Modena, Modena 41100, Italy). Fitoterapia, 54(5), 229-35 (Italian) 1983. CODEN: FTRPAE. ISSN: 0367-326X. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 11, 17 The compn. of 3 tarragon oils was detd. The oil from France contained mostly estragole [140-67-0], the oils from Germany and USSR mostly sabinene [3387-41-5] and elemicin [487-11-6]. The differences in morphol. of the foliar secretory tissues are discussed. .