Reference

Separation of amines by preferential aqueous salt extraction

Separation of amines by preferential aqueous salt extraction. Chang, Tzu Ching (du Pont de Nemours, E. I., and Co. , USA). U.S. US 4489209 A 18 Dec 1984, 6 pp. (English). (United States of America). CODEN: USXXAM. CLASS: ICM: C07C085-26. NCL: 564425000. APPLICATION: US 81-331894 17 Dec 1981. DOCUMENT TYPE: Patent CA Section: 45 (Industrial Organic Chemicals, Leather, Fats, and Waxes) Section cross-reference(s): 25 A process for sepg. 32 water-immiscible amines (esp. toluidine isomers) having basicity consts. between 1 ′ 10-10 and 20 ′ 10-10 and having basicity const. ratio 31.5:1 is described which comprises adding the amine mixt. to the midpoint of a countercurrent extractor, removing an org. phase contg. the less reactive amine from one end of the extractor, recovering part of the less reactive amine, neutralizing the rest of the less reactive amine with H2SO3, recycling the neutralized amine to the extractor, removing an aq. phase contg. the acid salt of the more reactive amine(s) from the extractor, reforming the free, more reactive amine(s) (esp. by heating) while recovering SO2 for use in neutralizing the less reactive amine, removing the aq. phase from the free, more reactive amine(s), removing part of the more reactive amine(s) from the system, and returning the rest of the more reactive amine(s) to the countercurrent extractor. Thus, the above process was used to sep. a mixt. of o-toluidine [95-53-4] 60, p-toluidine [106-49-0] 36, and m-toluidine [108-44-1] 4%. The org. phase comprised toluene. The sepn. process gave 3 isomers having purity 98.5-99.5%.

Toxicodynamic properties of toluidines

Toxicodynamic properties of toluidines. Part V. Methemoglobin producing action of toluidines. Senczuk, Witold; Rucinska, Hanna (Inst. Bioanal. Badania Srodowiska, Akad. Med., Poznan, Pol.). Bromatol. Chem. Toksykol., 17(3), 241-3 (Polish) 1984. CODEN: BCTKAG. ISSN: 0365-9445. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) In rats after intragastric administration of o-toluidine [95-53-4], m-toluidine [108-44-1], or p-toluidine (I) [106-49-0], metHb concns. in blood serum reached max. of 11.6, 36.4, and 21.7%, resp., after 1, 1, and 8 h, resp., and normalized after >48 h. Skin absorption of o-toluidine caused the slowest and I the fastest increases of metHb concns. in the blood serum.