CAS No.99469-99-5,3-Ethoxy-4-ethoxycarbonyl phenylacetic acid Suppliers

Products Categories

Pharmaceutical (136)
Others (35)
Organic Chemicals (29)
Reagent (5)
Materials (4)

Basic Information

Molecular Structure:
CAS No.:	99469-99-5
Name:	3-Ethoxy-4-ethoxycarbonyl phenylacetic acid
Article Data:	9

Formula:	C₁₃H₁₆O₅
Molecular Weight:	252.267
Synonyms:	3-Ethoxy-4-(ethoxycarbonyl)benzeneaceticacid;Ethyl 4-carboxymethyl-2-ethoxybenzoate;[3-Ethoxy-4-(ethoxycarbonyl)phenyl]aceticacid;3-Ethoxy-4-ethoxycarbonylphenyl acetic acid;
EINECS:	427-630-2
Density:	1.191 g/cm³
Melting Point:	78-80 °C
Boiling Point:	414.816 °C at 760 mmHg
Flash Point:	155.936 °C
Appearance:	white to pale yellow solid
Hazard Symbols:	Xi
Risk Codes:	41
Safety:	26-39
PSA:	72.83000
LogP:	1.88910

Synthetic route

: 332347-69-0
ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
With hydrogenchloride In water pH=3; Large scale;	90.5%
Stage #1: ethyl 2-ethoxy-4-ethoxycarbonylmethyl-benzoate With sodium hydroxide; water In methanol at 10 - 15℃; for 1 - 2h; Stage #2: With hydrogenchloride In water at 0 - 5℃; pH=3 - 4;	77.8%
With sodium hydroxide In ethanol at 23 - 25℃; for 1.5h;	59%
With water; sodium hydroxide In ethanol at 30℃; for 1h;

: 88709-18-6
2-ethoxy-4-methylbenzoic acid

: 616-38-6
carbonic acid dimethyl ester

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -80 - -70℃; for 4h; Temperature;	86.2%

: C16H22O5

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
With hydrogenchloride In water pH=3;	78.1%

: C17H24O5

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
With hydrogenchloride In water pH=3;	77.7%

: 124-38-9
carbon dioxide

: 88709-17-5
ethyl 2-ethoxy-4-methyl-benzoate

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -30℃; for 0.5h; Stage #2: ethyl 2-ethoxy-4-methyl-benzoate With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran; hexane at -75℃; for 2h; Stage #3: carbon dioxide In tetrahydrofuran; hexane at -75 - 10℃; for 0.5h;	72.7%
Stage #1: ethyl 2-ethoxy-4-methyl-benzoate With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃; Inert atmosphere; Industrial scale; Stage #2: carbon dioxide In tetrahydrofuran; hexane at -75℃; Industrial scale;	67%
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -30℃; for 0.5h; Stage #2: ethyl 2-ethoxy-4-methyl-benzoate With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran; hexane at -75℃; for 2h; Stage #3: carbon dioxide In tetrahydrofuran; hexane at -75 - 20℃;	59.5%
Stage #1: ethyl 2-ethoxy-4-methyl-benzoate With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere; Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78 - 10℃;	23%

: ethyl 2-ethoxy-5-(2-oxo-2-(quinolin-8-ylamino)ethyl)benzoate

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
Stage #1: ethyl 2-ethoxy-5-(2-oxo-2-(quinolin-8-ylamino)ethyl)benzoate With ozone In dichloromethane at -78℃; Inert atmosphere; Stage #2: With copper dichloride In 1,4-dioxane; water at 100℃; for 1h; Inert atmosphere; Microwave irradiation;	42%

: ethyl 4-(2-amino-2-oxoethyl)-2-ethoxybenzoate

A: 220438-80-2
2-ethoxy-[4-(carboxymethyl)]benzoic acid

B: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite at 35℃; for 2h;	A n/a B 39%

: 50-85-1
2-hydroxy-p-toluic acid

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: K2CO3 / diethyl ether / 30 h / 150 °C 2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4 3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 4: HCl / Heating 5: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C View Scheme
Multi-step reaction with 5 steps 1: K2CO3 / diethyl ether / 30 h / 150 °C 2: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4 3: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 4: aq. HCl / 1.5 h / 20 - 23 °C 5: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / dimethyl sulfoxide / 10.5 h / 40 °C 2.1: diisopropylamine; n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere 2.2: -78 - 10 °C View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / dimethyl sulfoxide / 11 h / 40 °C 2.1: diisopropylamine; n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere 2.2: -78 - 10 °C View Scheme

: 88709-17-5
ethyl 2-ethoxy-4-methyl-benzoate

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4 2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 3: HCl / Heating 4: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C View Scheme
Multi-step reaction with 4 steps 1: N-bromosuccinimide, 2,2'-azo-bis-(isobutyronitril) / CCl4 2: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 3: aq. HCl / 1.5 h / 20 - 23 °C 4: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C View Scheme
Multi-step reaction with 2 steps 1: dihydrogen peroxide; copper dichloride; bis(diphenylphosphino)ethylamine / tetrahydrofuran / 10 h / 15001.5 Torr / Reflux 2: hydrogenchloride / water / pH 3 View Scheme
Multi-step reaction with 2 steps 1: tert.-butylhydroperoxide; palladium dichloride; depe / tetrahydrofuran / 20 h / 15001.5 Torr / Reflux 2: hydrogenchloride / water / pH 3 / Large scale View Scheme

: 110017-07-7
ethyl 4-bromomethyl-2-ethoxy-benzoate

: 99469-99-5
2-(3-ethoxy-4-(ethoxycarbonyl)phenyl) acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 2: HCl / Heating 3: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C View Scheme
Multi-step reaction with 3 steps 1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C 2: aq. HCl / 1.5 h / 20 - 23 °C 3: 39 percent / aq. NaNO2, aq. HCl / 2 h / 35 °C View Scheme

Total:168 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 99469-99-5

Chemistry

Product Name: 4-Ethoxycarbonyl-3-ethoxyphenyla-cetic acid (CAS NO.99469-99-5)

IUPAC Name: 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid
Molecular Formula: C₁₃H₁₆O₅
Molecular Weight: 252.26
Appearance: white to pale yellow solid
Density: 1.191
Melting Point: 78-80 °C
Boiling Point: 414.8 °C at760mmHg
Flash Point: 155.9 °C
Surface Tension: 44.42 dyne/cm
Enthalpy of Vaporization: 70.41 kJ/mol
Index of Refraction: 1.527
Molar Refractivity: 65.084 cm³
Molar Volume: 211.785 cm³
Categories: Pharmaceutical material and intermeidates; Aromatic Phenylacetic Acids and Derivatives; Aromatics

Uses

4-Ethoxycarbonyl-3-ethoxyphenyla-cetic acid (CAS NO.99469-99-5) is used as an intermediate for the synthesis of Repaglinide.

Safety Profile

Safety Information of 4-Ethoxycarbonyl-3-ethoxyphenyla-cetic acid (CAS NO.99469-99-5):
Hazard Codes:Xi

Specification

4-Ethoxycarbonyl-3-ethoxyphenyla-cetic acid , its CAS NO. is 99469-99-5, the synonyms are 3-Ethoxy-4-(ethoxycarbonyl)benzeneacetic acid ; 2-[(4-Ethoxycarbonyl)-3-ethoxyphenyl] acetic acid .