128917-74-8Relevant articles and documents
Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells
Chiricozzi, Elena,Ciampa, Maria Grazia,Brasile, Giuseppina,Compostella, Federica,Prinetti, Alessandro,Nakayama, Hitoshi,Ekyalongo, Roudy C.,Iwabuchi, Kazuhisa,Sonnino, Sandro,Mauri, Laura
, p. 129 - 141 (2015)
Lactosylceramide [LacCer; β-Gal-(1-4)-β-Glc-(1-1)-Cer] has been shown to contain very long fatty acids that specifically modulate neutrophil properties. The interactions between LacCer and proteins and their role in cell signaling processes were assessed
Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics
Tarvainen, Ilari,Zimmermann, Tomá?,Heinonen, Pia,J?ntti, Maria Helena,Yli-Kauhaluoma, Jari,Talman, Virpi,Franzyk, Henrik,Tuominen, Raimo K.,Christensen, S?ren Br?gger
, p. 671 - 677 (2020)
Targeting cytotoxic 4β-phorbol esters toward cancer tissue was attempted by conjugating a 4β-pborbol derivative with substrates for the proteases prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) expressed in cancer tissue. The
A Light-up 1D supramolecular nanoprobe for silver ions based on assembly of pyrene-labeled peptide amphiphiles: Cell-imaging and antimicrobial activity
Kim, Inhye,Jeong, Heon-Ho,Kim, Yong-Jae,Lee, Na-Eun,Huh, Kang-Moo,Lee, Chang-Soo,Kim, Geon Hee,Lee, Eunji
, p. 6478 - 6486 (2014)
We prepared pyrene-labeled peptide amphiphiles (PAs) consisting of a hydrophobic linear- or branched-alkyl chain (for 1 or 2, respectively) and a hydrophilic histidine-rich peptide of HGGGHGHGGGHG (HG12). Both peptides have a strong tendency to form nanofibrils (NFs) in aqueous media. The resulting histidine-coated NFs show a great binding affinity to Cu2+ as a fluorescence light-off sensor. Interestingly, the emission spectra of the pyrene probe show that the different supramolecular assemblies between 1 and 2 can significantly affect the binding affinity to specific metal ions. In particular, light-up fluorescent Ag+ detection of NFs of 2 through inhibition of photoinduced electron transfer (PET) was observed even at a low concentration of PA solution. As a means to determine the biological responsibility of 2 to Ag+, intracellular detection using the turn-on response was performed. A considerable enhancement of fluorescence in NF-loaded HeLa cells was observed. In addition, the NFs were used as a template scaffold for the production of Ag nanoparticles (AgNPs) with high monodispersity and stability. The NFs decorated with AgNPs are shown to possess highly effective and long-term antibacterial activity against both Gram-negative and -positive bacteria.
