5999-14-4Relevant articles and documents
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Arnold et al.
, p. 565,567 (1958)
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Polymerization and copolymerization of olefins and acrylates by bis(benzimidazole) copper catalysts
Stibrany, Robert T.,Schulz, Donald N.,Kacker, Smita,Patil, Abhimanyu O.,Baugh, Lisa S.,Rucker, Steven P.,Zushma, Stephen,Berluche, Enock,Sissano, Joseph A.
, p. 8584 - 8586 (2003)
CuBBIM/MAO is a highly versatile catalyst system that homopolymerizes ethylene and acrylates and, more significantly, induces ethylene/acrylate copolymerization. This new system is remarkable in spanning homopolymerization space broadly, while still enabling copolymerization of these traditionally transition-metal-catalyzed incompatible monomer classes.
STRUCTURAL FEATURES OF CADMIUM(II) COMPLEXES WITH BIS(BENZIMIDAZOL-2-YL)METHANE
Adonin, S. A.,El’tsov, I. V.,Lider, E. V.,Smirnova, K. S.,Sukhikh, T. S.
, p. 718 - 726 (2021/06/21)
Abstract: A series of cadmium(II) coordination compounds with bis(benzimidazol-2-yl)methane (L) is synthesized. Single crystals are obtained, and molecular and crystal structures of [Cd4(L)4Cl6(EtOH)0.77(H2O)1.23] [CdCl4]·H2O·5EtOH, [Cd(L)I2], and [Cd(L)2(EtOH)2][Cd(L)(NO3)3]2·6EtOH complexes are determined. According to the single crystal X-ray diffraction analysis, the organic ligand has a bidentate cyclic coordination. Distinctions in the structures of the compounds depending on the anion present are observed. The [Cd(L)I2] complex is mononuclear with cadmium ions are in the tetrahedral environment. Cadmium chloride and nitrate complexes are cationic-anionic with cadmium ions in different environments, and their coordination numbers vary in the range of 4-7.
Bisbenzimidazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation and Pharmacophore Analysis
Ersan, Ronak Haj,Bolelli, Kayhan,Gonca, Serpil,Dogen, Aylin,Burmaoglu, Serdar,Algul, Oztekin
, p. 149 - 158 (2021/05/13)
In an attempt to design and synthesize a potent class of antimicrobials, 1,2-phenylenediamine derivatives were reacted with various aliphatic and heteroaliphatic dicarboxylic acids to generate a small library of 26 head-to-head bisbenzimidazole compounds (16 – 42) using the polyphosphoric acid method. These compounds were screened for their antibacterial activity and their antifungal activity. Compound 25 showed maximum potency against both Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 7.81 – 31.25 μg/mL. In particular, it showed the maximum MIC values of 7.81 μg/mL against Gram-negative bacteria, which was four-fold more active than the standard drug ampicillin (MIC = 32.25 μg/mL). Compound 19 was found to be the most active against S. aureus with a MIC value of 3.90 μg/mL, whereas the remaining compounds showed only low-to-moderate activity. Furthermore, all compounds exhibited low activity against all fungal strains in comparison to the standard drug fluconazole. I addition, pharmacophore hypotheses were generated to analyze structure–activity relationships between the molecular structures and antimicrobial activities on E. coli. This pharmacophore model can be useful in order to design new antimicrobial drugs. It can be suggested that the substitution of a phenyl ring at the 5/6 and 5′/6′ positions in symmetric bisbenzimidazole derivatives produces compounds with promising antimicrobial activity.
