100331-93-9

Basic information

• Product Name: 5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide
• Synonyms: 1-[1-Oxido-8-(phenylMethoxy)-5-quinolinyl]-ethanone;1-[8-(PhenylMethoxy)-5-quinolinyl]-ethanone N-Oxide;5-Acetyl-8-(benzyloxy)quinoline N-Oxide;5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide
• CAS NO: 100331-93-9
• Molecular Formula: C₁₈H₁₅NO₃
• Molecular Weight: 291
• Product Categories: Pharmaceuticals;Aromatics;Heterocycles;Intermediates & Fine Chemicals
• Mol File: 100331-93-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 136.5-137.5 °C
• Boiling Point: 526.2±58.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• Solubility: Methanol
• PKA: -0.50±0.30(Predicted)
• CAS DataBase Reference: 5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide(100331-93-9)
• EPA Substance Registry System: 5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide(100331-93-9)

Safety Data

• Hazardous Substances Data: 100331-93-9(Hazardous Substances Data)

Usage

Description

5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide is a light brown solid with unique chemical properties that make it a valuable compound in the field of pharmaceuticals and organic chemistry.

Uses

Used in Pharmaceutical Industry:
5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide is used as a key intermediate in the synthesis of phenylethanolamine derivatives, which are known as β2 adrenoreceptor agonists. These agonists play a crucial role in the treatment of various respiratory conditions, such as asthma and chronic obstructive pulmonary disease (COPD), by relaxing the smooth muscles in the airways and improving lung function.
Additionally, due to its unique chemical structure, 5-Acetyl-8-(phenylMethoxy)-2-quinoline N-Oxide may also have potential applications in other areas of the pharmaceutical industry, such as the development of new drugs targeting different receptors or enzymes. However, further research and development would be required to explore these possibilities.

Upstream product

• 100-39-0 benzyl bromide 
• 57434-96-5 5-acetyl-8-hydroxyquinoline hydrochloride 
• 2598-31-4 5-acetyl-8-hydroxyquinoline 
• 148-24-3 8-quinolinol 
• 26872-48-0 1-(8-benzyloxyquinolin-5-yl)ethanone 

Downstream Products

• 530084-79-8 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one 
• 100331-89-3 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one 
• 173140-90-4 (R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone 
• 100429-06-9 8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)amino]ethyl}carbostyril 
• 1052689-06-1 8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((lR)-2-(p-methoxy phenyl)-1-methylethyl) amino] ethyl} carbostyril hydrochloride 
• 100429-08-1 8-hydroxy-5-((1R)-1-hydroxy-2-(N-((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)carbostyril hydrochloride 
• 93609-84-8 5-acetyl-8-benzyloxy-1H-quinolin-2-one 

Relevant articles and documents

PROCESS FOR PREPARING ISOMERS OF CARMOTEROL

A process for preparing a compound of formula (III) comprising condensing an oxiranyl compound of formula (I) with an amine of formula (II) or a salt thereof wherein: R1 is a group selected from alkyl, aryl, allyl, alkoxy, cycloalkyl, heterocyclic, alkenyl, benzocycloalkyl, aralkyl, haloarylalkyl, heteroaralkyl, haloalkyl, alkoxyaralkyl, substituted silyl and benzyl; and R2 is hydrogen, optionally substituted silyl or optionally substituted benzyl. Formula (I), (II) and (III): There is also described a process for preparing (R,R)-carmoterol from compound (III).