10045-25-7Relevant articles and documents
SYNTHESIS AND ACID-BASE AND COMPLEX-FORMING PROPERTIES OF 1,4,7,10-TETRAKIS(DIHYDROXYPHOSPHORYLMETHYL)-1,4,7,10-TETRAAZACYCLODODECANE
Kabachnik, M. I.,Medved', T. Ya.,Bel'skii, F. I.,Pisareva, S. A.
, p. 777 - 782 (1984)
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Condensation of glyoxal with triethylenetetraamine. Stereochemistry, cyclization and deprotection
Herve, Gwenaelle,Bernard, Helene,Bris, Nathalie Le,Baccon, Michel Le,Yaouanc, Jean-Jacques,Handel, Henri
, p. 2517 - 2520 (1999)
A mixture of bis-aminal isomers was obtained from aqueous glyoxal- triethylenetetraamine condensation. The irreversible isomerization of the species was observed and a new synthesis of cyclen proposed.
A new route to cyclen, cyclam and homocyclen
Herve, Gwenaelle,Bernard, Helene,Le Bris, Nathalie,Yaouanc, Jean-Jacques,Handel, Henri,Toupet, Loic
, p. 6861 - 6864 (1998)
Cyclen, cyclam and homocyclen have been synthesized from the corresponding butanedione-protected linear tetramines. The cyclization step is followed by a facile deprotection of the rigidifying moiety.
Preparation method of cyclen
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Paragraph 0057; 0058; 0059, (2020/02/14)
The invention provides a preparation method of cyclen. The method comprises the following step: taking triethylenetetramine (TETA) as a raw material to carry out refining, then carrying out a reactionon the refined triethylenetetramine with methylglyoxal to obtain an intermediate 2, carrying out cyclization on the intermediate 2 with glyoxal, carrying out reducing with sodium borohydride to obtain a cyclized intermediate 3, finally carrying out ring opening through acid hydrolysis, and then adjusting the pH value by using an alkali solution to free out the cyclen.
A high-purity torus cane rather method for the preparation of
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Paragraph 0065-0082; 0087; 0092-0093, (2017/03/21)
The invention provides a preparation method of high-purity cyclen. The method comprises the following preparation paths. Cyclen obtained by the method of the invention has high purity. At the same time, the method greatly reduces the energy consumption and the power cost, and thereby reducing the raw material cost; the method greatly improves the reaction rate, reduces the catalyst amount and the reaction temperature, thereby shortening the consuming time of the process, and reducing the process cost; and the method greatly reduces the acid amount consumption, and thereby greatly reducing the equipment loss. The preparation method improves the production efficiency, and enables the product quality to reach more than 99.8%; hydrazine hydrate is used for replacing diethylenetriamine for a hydrolysis reaction, so the process is suitable for industrialized production. The method of the invention is environmentally friendly, is cost-saving, and is suitable for environment-friendly industrialization.