91987-74-5

Basic information

• Product Name: 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAYL-TETRAKIS(METHYLPHOSPHONIC ACID)
• Synonyms: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonicacid;1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAYL-TETRAKIS(METHYLPHOSPHONIC ACID);1,4,7,10-tetraazacyclododecane-tetrayl-tetrak.(me.phosph.ac;1 4 7 10-TETRAAZACYCLODODECANE-TETRAYL-&;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid);1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid;DOTMP;CB-TE2A(M-220)
• CAS NO: 91987-74-5
• Molecular Formula: C12H32N4O12P4
• Molecular Weight: 548.3
• EINECS: 224-025-3
• Product Categories: Organic Building Blocks;Phosphonic/Phosphinic Acids;Phosphorus Compounds
• Mol File: 91987-74-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 280℃ (DEC.)
• Boiling Point: 921.6°Cat760mmHg
• Flash Point: 511.2°C
• Appearance: /
• Density: 1.622
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAYL-TETRAKIS(METHYLPHOSPHONIC ACID)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAYL-TETRAKIS(METHYLPHOSPHONIC ACID)(91987-74-5)
• EPA Substance Registry System: 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAYL-TETRAKIS(METHYLPHOSPHONIC ACID)(91987-74-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 91987-74-5(Hazardous Substances Data)

Usage

Uses

DOTP could be a useful cancer diagnostic imaging agent.

InChI:InChI=1/C12H32N4O12P4/c17-29(18,19)9-13-1-2-14(10-30(20,21)22)5-6-16(12-32(26,27)28)8-7-15(4-3-13)11-31(23,24)25/h1-12H2,(H2,17,18,19)(H2,20,21,22)(H2,23,24,25)(H2,26,27,28)

Upstream product

• 60239-18-1 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane 
• 137837-23-1 Et₈DOTP 
• 749834-55-7 [Eu(1,4,7,10-tetraazocyclododecane-1,4,7,10-tetrakis(methylphosphonic acid(-8H)))]^(5-) 
• 7732-18-5 water 
• 50-00-0 formaldehyd 
• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 10045-25-7 1,4,7,10-tetraazacyclododecane tetrahydrochloride 

Downstream Products

• 1174374-75-4 [Gd(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylphosphonate))]5^- 

Relevant articles and documents

Lanthanide(III) complexes of phosphorus acid analogues of H4DOTA as model compounds for the evaluation of the second-sphere hydration

Five DOTA-like ligands lacking a water molecule in the first coordination sphere of their GdIII complexes, namely the phosphinates H 4DOTPH, H4DOTPhm and H 4DOTPEt, and the phosp

Kinetic study of dissociation of Eu(III) complex with H8dotp (H8dotp = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid))

The dissociation kinetics of the europium(III) complex with H8dotp ligand was studied by means of molecular absorption spectroscopy in UV region at ionic strength 3.0 mol dm-3 (Na,H)ClO4 and in temperature region 25-60 °C.

METHOD FOR THE SYNTHESIS OF ALPHA-AMINOALKYLENEPHOSPHONIC ACID

The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P-O-P anhydride moiety comprising compound, having one P-atom at the oxidation state (+111) and the other P-atom at the oxidation state (+111) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P-O-P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.