71989-26-9

Basic information

• Product Name: N-alpha-FMOC-Nepsilon-BOC-L-Lysine
• Synonyms: N^e-Boc-N^a-FMoc-L-lysine, 98%;Nα-FMoc-Nε-Boc-L-lysine;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-6-((tert-butoxycarbonyl)aMino)hexanoic acid;FMoc-Lys(Boc)-OH >=98.0% (HPLC);Fmoc-Lys(Boc)-OH(CAS:71989-26-9);L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (13C6;L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (1-13C);Nε-(tert-Butoxycarbonyl)-Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine
• CAS NO: 71989-26-9
• Molecular Formula: C₂₆H₃₂N₂O₆
• Molecular Weight: 468.54
• EINECS: 276-256-4
• Product Categories: Amino Acid Derivatives;Amino Acids;Lysine [Lys, K];Fmoc-Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Fmoc-Amino Acids;Fmoc-Amino acid series
• Mol File: 71989-26-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 130-135 °C (dec.)
• Boiling Point: 570.69°C (rough estimate)
• Flash Point: 368.5 °C
• Appearance: White/Powder
• Density: 1.2301 (rough estimate)
• Refractive Index: -12 ° (C=1, DMF)
• Storage Temp.: 2-8°C
• PKA: 3.88±0.21(Predicted)
• Water Solubility: Slightly soluble in water.
• Stability: Stable. Incompatible with strong oxidizing agents.
• BRN: 4217767
• CAS DataBase Reference: N-alpha-FMOC-Nepsilon-BOC-L-Lysine(CAS DataBase Reference)
• NIST Chemistry Reference: N-alpha-FMOC-Nepsilon-BOC-L-Lysine(71989-26-9)
• EPA Substance Registry System: N-alpha-FMOC-Nepsilon-BOC-L-Lysine(71989-26-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25-36/37/39-27-26
• WGK Germany: 3
• Hazardous Substances Data: 71989-26-9(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

Different sources of media describe the Uses of 71989-26-9 differently. You can refer to the following data:
1. It is used to prepare dimeric RGD peptide-paclitaxel conjugate as model for integrin-targeted drug delivery. It is also used to synthesize DOTA-conjugated multivalent cyclic-RGD peptide dendrimers for tumor targeting and imaging use.
2. Fmoc-Lys(Boc)-OH can be used for:The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as 19F NMR based screening tool.

InChI:InChI=1/C26H32N2O6/c1-26(2,3)34-24(31)27-15-9-8-14-22(23(29)30)28-25(32)33-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H,27,31)(H,28,32)(H,29,30)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 56-87-1 L-lysine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 657-27-2 L-Lysine hydrochloride 
• 2418-95-3 (S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 2418-95-3 H-Lys(Boc)-OH 

Downstream Products

• 113534-31-9 Fmoc-Lys(Boc)-OTDO 
• 86060-98-2 Fmoc-L-Lys(Boc)-OPfp 
• 193156-86-4 α-N(Fmoc)-ε-N(tBoc)-L-Lys-Gly-OBn 
• 255851-82-2 {2-[6-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoylamino]-acetylamino}-acetic acid benzyl ester 

Relevant articles and documents

PROPYL CATIONIC PEPTIDE LIPIDS, SYNTHESIS METHOD THEREOF, AND APPLICATION THEREOF

A class of propyl cationic peptide lipids is propyl cationic peptide lipid compounds having a general formula structure as follows. After the propyl cationic peptide lipids are dispersed in water, a cationic liposome with a particle size of approximately 100 nm is obtained. The cationic liposome can carry plasmid DNA (pDNA) or small interfering RNA (siRNA) into cells to realize the function of gene delivery, and is almost non-toxic to the cells.

Caged xanthones: Potent inhibitors of global predominant MRSA USA300

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Tri-peptide cationic lipids for gene delivery

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