1064681-06-6

Basic information

• Product Name: N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-bromo-2-trifluoromethoxybenzenesulfonamide
• Synonyms: N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-bromo-2-trifluoromethoxybenzenesulfonamide
• CAS NO: 1064681-06-6
• Molecular Weight: 630.439
• Mol File: 1064681-06-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-bromo-2-trifluoromethoxybenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-bromo-2-trifluoromethoxybenzenesulfonamide(1064681-06-6)
• EPA Substance Registry System: N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-bromo-2-trifluoromethoxybenzenesulfonamide(1064681-06-6)

Safety Data

• Hazardous Substances Data: 1064681-06-6(Hazardous Substances Data)

Upstream product

• 127399-79-5 2-(benzyloxy)-1,6-dibromonaphthalene 
• 66996-59-6 1,6-dibromo-2-methoxynaphthalene 
• 16239-18-2 1,6-dibromo-2-naphthol 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 1365958-40-2 2-(benzyloxy)-6-(3-(benzyloxy)phenyl)-1-bromonaphthalene 
• 1365958-59-3 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-4-bromo-2-(trifluoromethoxy)benzenesulfonamide 
• 1365958-43-5 3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)aniline 
• 1064681-42-0 3-(2-methoxy-6-(3-methoxyphenyl)naphthalen-1-yl)aniline 
• 1041115-67-6 1-bromo-2-methoxy-6-(3-methoxyphenyl)naphthalene 
• 175278-14-5 4-bromo-2-(trifluoromethoxy)benzene-1-sulfonyl chloride 
• 1064680-92-7 1-(3-aminophenyl)-6-(3-hydroxyphenyl)naphthalen-2-ol 

Relevant articles and documents

Lead optimization of 17β-HSD1 inhibitors of the (hydroxyphenyl) naphthol sulfonamide type for the treatment of endometriosis

The reduction of estrone to estradiol, the most potent estrogen in human, is catalyzed by 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1). A promising approach for the treatment of estrogen-dependent diseases is the reduction of intracellular estradiol formation by inhibition of 17β-HSD1. For the species-specific optimization of the (hydroxyphenyl)naphthols, a combinatorial approach was applied and enhanced by a focused synthesis that resulted in the aromatic-substituted (hydroxyphenyl)naphthol sulfonamides. Rigidification of 12 led to the 4-indolylsulfonamide 30, which is a highly active and selective human 17β-HSD1 inhibitor, as well as a highly potent and selective inhibitor of 17β-HSD1 from Callithrix jacchus. It shows no affinity to the estrogen receptors I?± and β and good intracellular activity (T47D). Thus, compound 30 shows good properties for further ADMET studies and might be a candidate for the in vivo proof of concept in C. jacchus.