1074-41-5Relevant articles and documents
Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents
Abu-Hashem, Ameen A.,Hussein, Hoda A. R.,Abu-zied, Khadeja M.
, p. 120 - 130 (2017)
Abstract: 7-aminopyrimidin-5(1H)-one (5) was utilized as a starting material for the preparation of new, Schiff bases (13–19), amides 23, 24, imide 25, as well as thiourea derivatives 30–33 incorporating the triazolopyrimidines nucleus in their molecules. Structural elucidations for the new compounds were based upon compatible microanalytical and spectroscopic measurement. Biological evaluation indicated that compounds 23, 31, 33, 32, and 30 possess promising antimicrobial activities. Graphical Abstract: [InlineMediaObject not available: see fulltext.]
Pyrimidinone derivative, preparation method thereof and application thereof in resisting mycobacterium tuberculosis infection
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Paragraph 0157-0162, (2020/11/25)
The invention discloses a pyrimidinone derivative, a preparation method thereof and an application thereof in resisting mycobacterium tuberculosis infection. The structure of the pyrimidinone derivative is shown as a formula I, wherein R1, m, X, Y, Z, R2
PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 98, (2019/09/04)
New pyrimidine derivatives of formula (I), optionally with a detectable isotope, pharmaceutical composition and method of preparation thereof. New pyrimidine derivatives for use in treatment or prevention of bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives for use as radiotracer in diagnosing or prognosing bacterial infection in a host mammal.