114095-61-3

Basic information

• Product Name: (trans-2-(4-methylphenyl)cyclopropyl)methanol
• Synonyms: (trans-2-(4-methylphenyl)cyclopropyl)methanol
• CAS NO: 114095-61-3
• Molecular Weight: 162.232
• Mol File: 114095-61-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (trans-2-(4-methylphenyl)cyclopropyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (trans-2-(4-methylphenyl)cyclopropyl)methanol(114095-61-3)
• EPA Substance Registry System: (trans-2-(4-methylphenyl)cyclopropyl)methanol(114095-61-3)

Safety Data

• Hazardous Substances Data: 114095-61-3(Hazardous Substances Data)

Usage

Description

(trans-2-(4-methylphenyl)cyclopropyl)methanol is a colorless liquid chemical compound characterized by a cyclopropyl group and a methylphenyl group attached to a methanol functional group in a trans orientation. This unique molecular structure endows the compound with distinctive reactivity, making it a valuable building block for the synthesis of other complex organic molecules.

Uses

Used in Organic Synthesis:
(trans-2-(4-methylphenyl)cyclopropyl)methanol is utilized as a key intermediate in organic synthesis, particularly for the creation of complex organic molecules. Its cyclopropyl group contributes to its unique reactivity, which is beneficial for the development of novel chemical structures.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (trans-2-(4-methylphenyl)cyclopropyl)methanol is employed as a starting material for the research and development of new pharmaceuticals. Its unique molecular structure and reactivity make it a promising candidate for the synthesis of innovative drug compounds.
Used in Antibiotic Development:
Studies have indicated that (trans-2-(4-methylphenyl)cyclopropyl)methanol may have potential applications in the development of new antibiotics. Its unique molecular structure and reactivity could be harnessed to create novel antibiotics with enhanced efficacy against drug-resistant bacteria.
Used in Pharmaceutical Development:
Due to its distinctive molecular structure and reactivity, (trans-2-(4-methylphenyl)cyclopropyl)methanol is also considered for use in the development of new pharmaceuticals. Further research is necessary to fully understand its potential applications and to unlock its full potential in the pharmaceutical industry.

Upstream product

• 97023-67-1 ethyl 2-(4-methylphenyl)cyclopropane-1-carboxylate 
• 75-11-6 diiodomethane 
• 122058-30-4 4-methylcinnamyl alcohol 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 18456-66-1 (1R*,2R*)-ethyl 2-(p-tolyl)cyclopropanecarboxylate 
• 16633-44-6 (±)-trans-2-p-tolylcyclopropanecarboxylic acid 
• 141750-54-1 (2E)-N-methoxy-N-methyl-3-(4-methylphenyl)acrylamide 
• 72228-97-8 methyl trans-2-(p-methyphenyl)cyclopropanecarboxylate 
• 20754-20-5 3-p-tolyl-acrylic acid methyl ester 
• 1866-39-3 trans-p-methylcinnamic acid 
• 97585-04-1 ethyl (E)-3-(4-methylphenyl)acrylate 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 132145-62-1 trans-2-(p-tolyl)cyclopropane-1-carbaldehyde 
• 153198-69-7 2-(p-tolyl)cyclopropanecarbaldehyde 
• 132145-62-1 2-(p-tolyl)cyclopropanecarbaldehyde 
• 71104-59-1 cis-<2-(p-methylphenyl)cyclopronyl>methyl acetate 
• 4076-61-3 trans-1-methyl-2-(4-methylphenyl)cyclopropane 
• 71104-59-1 trans-<2-(p-methylphenyl)cyclopropyl>methyl acetate 

Relevant articles and documents

Enantioselective Copper-Catalyzed 1,5-Cyanotrifluoromethylation of Vinylcyclopropanes

A copper-catalyzed enantioselective 1,5-cyanotrifluoromethylation of vinylcyclopropanes has been developed using a radical relay strategy. This asymmetric reaction has demonstrated high enantioselective control, broad substrate scope, and mild conditions. Initiated by the in situ generated CF3 radical from Togni's reagent, this method offers a new solution for remote enantioselective bifunctionalization of alkenes and thus provides a straightforward way for the synthesis of chiral CF3-containing internal alkenylnitriles.

Metal-free domino Cloke-Wilson rearrangement-hydration-dimerization of cyclopropane carbaldehydes: A facile access to oxybis(2-aryltetrahydrofuran) derivatives

In this work, we have demonstrated a metal-free transformation of cyclopropane carbaldehydes to oxybis(2-aryltetrahydrofuran) derivatives via a domino Cloke-Wilson rearrangement-hydration-dimerization sequence. Commercially inexpensive p-toluene sulfonic acid (PTSA) was used as a Br?nsted acid catalyst, and reactions were conducted in an open-flask. Detection of reaction intermediates were carried to get an insight into the reaction pathway.

Accessing dihydro-1,2-oxazine via cloke-wilson-type annulation of cyclopropyl carbonyls: application toward the diastereoselective synthesis of pyrrolo[1,2- b][1,2]oxazine

A convenient additive-free synthesis of dihydro-4H-1,2-oxazines via a Cloke-Wilson-type ring expansion of the aryl-substituted cyclopropane carbaldehydes with the hydroxylamine salt is introduced. Comparatively less active cyclopropyl ketones also follow a similar protocol if supplemented by catalytic p-toluene sulfonic acid monohydrate. The transformation is performed in an open-to-air flask as it shows negligible sensitivity toward air/moisture. Dihydro-4H-1,2-oxazines when subjected to cycloaddition with the cyclopropane diester afford a trouble-free formulation of the valued hexahydro-2H-pyrrolo[1,2-b][1,2]oxazine derivatives. A cascade one-pot variant of this two-step strategy offers a comparable overall yield of the final product.