1256815-17-4Relevant articles and documents
Convenient synthesis of novel 2-substituted imidazopyrazinone derivatives
Zhu, Yanyun,Song, Gonghua,Lu, Peng,Zhu, Mingjie,Chen, Yilang
, p. 469 - 479 (2011/11/29)
Starting from commercially available piperazine-2-carboxylic acid, a series of novel 2-aryl and 2-benzyl substituted imidazopyrazinone were prepared. The intermediates 5a-g were obtained through facile Buchwald-Hartwig coupling reaction, and the effects of catalyst, base, and solvent on the coupling reaction were investigated. The optimal reaction conditions for the coupling reaction were PdCl2(dppf)=NaO-t-Bu=toluene. Taylor & Francis Group, LLC.