1259017-71-4

Basic information

• Product Name: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine
• Synonyms: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine
• CAS NO: 1259017-71-4
• Molecular Weight: 472.346
• Mol File: 1259017-71-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine(1259017-71-4)
• EPA Substance Registry System: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine(1259017-71-4)

Safety Data

• Hazardous Substances Data: 1259017-71-4(Hazardous Substances Data)

Upstream product

• 443882-99-3 3-chloro-4-(3-fluorobenzyloxy)nitrobenzene 
• 230955-54-1 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl acetate 
• 179246-11-8 4-chloroquinazoline-6-yl acetate 
• 16064-10-1 6-hydroxyquinazolin-4(3H)-one 
• 109-70-6 1.3-chlorobromopropane 
• 230955-55-2 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-ol 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 179688-15-4 4-hydroxyquinazoline-6-yl acetate 

Downstream Products

• 1259017-44-1 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate 

Relevant articles and documents

HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and in Vitro and in Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability

HER2 kinase as a well-established target for breast cancer (BC) therapy is associated with aggressive clinical outcomes; thus, herein we present structural optimization for HER2-selective targeting. HER2 profiling of the developed derivatives demonstrated