230955-54-1

Basic information

• Product Name: 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl acetate
• Synonyms: 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl acetate
• CAS NO: 230955-54-1
• Molecular Weight: 437.858
• Mol File: 230955-54-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl acetate(230955-54-1)
• EPA Substance Registry System: 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl acetate(230955-54-1)

Safety Data

• Hazardous Substances Data: 230955-54-1(Hazardous Substances Data)

Upstream product

• 443882-99-3 3-chloro-4-(3-fluorobenzyloxy)nitrobenzene 
• 16064-10-1 6-hydroxyquinazolin-4(3H)-one 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 179688-15-4 4-hydroxyquinazoline-6-yl acetate 
• 179688-15-4 3,4-dihydro-4-oxoquinazolin-6-yl acetate 
• 202197-26-0 3-chloro-4-(3-fluorobenzyloxy)aniline 
• 179246-11-8 4-chloroquinazoline-6-yl acetate 

Downstream Products

• 1259017-44-1 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate 
• 1259017-71-4 N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)quinazolin-4-amine 
• 230955-71-2 N-(4-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yloxy}-butyl)-2,2,2-trifluoro-N-(2-methanesulfonyl-ethyl)-acetamide 
• 230955-55-2 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-ol 

Relevant articles and documents

HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and in Vitro and in Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability

HER2 kinase as a well-established target for breast cancer (BC) therapy is associated with aggressive clinical outcomes; thus, herein we present structural optimization for HER2-selective targeting. HER2 profiling of the developed derivatives demonstrated

QUINAZOLINE DERIVATIVES,PREPARATION METHODS AND USES THEREOF

The present invention has disclosed a compound of formula I and a pharmaceutically acceptable salt or a solvate thereof, wherein the substituents are as defined in the description. The invention has also disclosed a method for preparing the compound of formula I, the pharmaceutical compositions comprising the same and their uses in the preparation of an anti- tumor medicament.

MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS

The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.