125923-35-5Relevant articles and documents
An organocatalytic cascade strategy for the enantioselective construction of spirocyclopentane bioxindoles containing three contiguous stereocenters and two spiro quaternary centers
Sun, Wangsheng,Zhu, Gongming,Wu, Chongyang,Hong, Liang,Wang, Rui
supporting information; experimental part, p. 6737 - 6741 (2012/07/28)
A rapid and efficient organocatalytic cascade sequence for the direct construction of spirocyclopentane bioxindoles has been carried out by using a chiral squaramide catalyst in the presence of a base. This process constitutes a powerful approach to the preparation of biologically important bispirooxindoles in high enantioselectivities (see scheme). Copyright
Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives
Suarez-Castillo, Oscar R.,Melendez-Rodriguez, Myriam,Castelan-Duarte, Luis Enrique,Sanchez-Zavala, Maricruz,Rivera-Becerril, Ernesto,Morales-Rios, Martha S.,Joseph-Nathan, Pedro
experimental part, p. 2374 - 2389 (2010/03/24)
We describe a reliable method for determining the absolute configuration of 2-(2-oxo-3-indolyl)acetamides based on analysis of the 1H NMR spectra of their phenylethylamide diastereomers. The conformational preferences for two diastereomeric ami
REACTIONS OF β-KETO ESTERS WITH 2-CYANO-1,2,5,6-TETRAHYDROPYRIDINES
Chapman, R. F.,Phillips, N. I. J.,Ward, R. S.
, p. 5229 - 5234 (2007/10/02)
Reaction of the sodium salts of β-keto esters 13a and 13b with the 2-cyano-tetrahydropyridines 11 and 12 afforded the 4-substituted piperidine derivatives 21-23.The structures were assigned on the basic of their (1)H-and (13)C-NMR spectra and by comparison with the model compounds 24-26.The stereochemistry and the mechanism of the reactions are discussed.
