4276-26-0 Usage
Description
(N1-benzyl-3-indolyl)acetamide, with the molecular formula C18H17N2O, is a chemical compound derived from the indole class of heterocyclic aromatic organic compounds. It features a benzyl group attached to the N^1 position of the indole ring, which is connected to an acetamide group. (N1-benzyl-3-indolyl)acetamide is widely utilized in organic synthesis and medicinal chemistry as a fundamental building block for creating various pharmaceutical compounds and biologically active molecules. Its unique structure and potential pharmacological properties make it a valuable candidate for drug development and research.
Uses
Used in Pharmaceutical Compounds Synthesis:
(N1-benzyl-3-indolyl)acetamide is used as a key building block in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the creation of a diverse range of biologically active molecules, contributing to the development of new drugs and treatments.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (N1-benzyl-3-indolyl)acetamide serves as an essential component in the study and development of novel drug candidates. Its potential pharmacological properties make it a valuable tool for researchers working on drug discovery and the advancement of medical treatments.
Used in Drug Development:
(N1-benzyl-3-indolyl)acetamide is employed in drug development as a starting material for the creation of new pharmaceutical agents. Its structural versatility and potential pharmacological activities enable the design and synthesis of innovative drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the realm of organic synthesis, (N1-benzyl-3-indolyl)acetamide is utilized as a versatile intermediate for the preparation of a wide array of organic compounds. Its unique structure and reactivity make it a valuable asset in the synthesis of complex organic molecules for various applications, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 4276-26-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,7 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4276-26:
(6*4)+(5*2)+(4*7)+(3*6)+(2*2)+(1*6)=90
90 % 10 = 0
So 4276-26-0 is a valid CAS Registry Number.
4276-26-0Relevant articles and documents
Effect of indole-3-acetic acid analogs on the differentiation of HL-60 cells
Lien, Jin-Cherng,Jiang, Yu-Dong,Chen, Chun-Jen,Kuo, Sheng-Chu,Huang, Li-Jiau
experimental part, p. 1160 - 1165 (2009/12/08)
In continuing search for novel cell differentiation agents, a series of derivatives of indole-3-acetic acid and indole-3-carboxylic acid were prepared and tested against HL-60 cells for their differentiation and antiproliferation activities. Among them, N-ethyl-1-benzylindole-3-carboxamide (14) was the most potent, whereas N-methyl 1-benzylindole-3-acetamide (5) and N-methyl 1-benzylindole-3-carboxamide (13) synergistically potentiated with all-trans-retinoic acid to induce cell differentiation as well as antiproliferation. Our results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid.
Construction of indole and benzofuran systems on the solid phase via palladium-mediated cyclizations
Zhang, Han-Cheng,Maryanoff, Bruce E.
, p. 1804 - 1809 (2007/10/03)
Molecular diversity in the area of nonpeptide, small organic molecules has been receiving considerable attention in the chemical community. Herein, we report new solid-phase methodology for the rapid generation of such small-molecule libraries by simultaneous-parallel or combinatorial synthesis. We have adapted a palladium-mediated, intramolecular Heck-type reaction, a mild and versatile method for carbon-carbon bond formation, to the solid phase. This has been applied to the synthesis of diverse indole and benzofuran derivatives, such as 8, 15, and 28, in good to excellent yields.
