1276635-21-2

Basic information

• Product Name: 4-benzoylbenzaldehyde dimethyl acetal
• Synonyms: 4-benzoylbenzaldehyde dimethyl acetal
• CAS NO: 1276635-21-2
• Molecular Weight: 256.301
• Mol File: 1276635-21-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzoylbenzaldehyde dimethyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzoylbenzaldehyde dimethyl acetal(1276635-21-2)
• EPA Substance Registry System: 4-benzoylbenzaldehyde dimethyl acetal(1276635-21-2)

Safety Data

• Hazardous Substances Data: 1276635-21-2(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 5908-41-8 benzoyltrimethylsilane 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 611-74-5 N,N-dimethylbenzamide 

Downstream Products

• 1276664-79-9 4-(exo-6-bicyclo[3.1.0]hexyl)benzophenone 
• 1276664-81-3 4-(2,3-dimethylcyclopropyl)benzophenone 
• 1276635-07-4 p-benzoylphenyldiazomethane 
• 1276634-93-5 4-(endo-6-bicyclo[3.1.0]hexyl)benzophenone 
• 20912-50-9 4-benzoylbenzaldehyde 

Relevant articles and documents

Reversed-polarity synthesis of diaryl ketones via palladium-catalyzed cross-coupling of acylsilanes

Acylsilanes serve as acyl anion equivalents in a palladium-catalyzed cross-coupling reaction with aryl bromides to give unsymmetrical diaryl ketones. Water plays a unique and crucial activating role in these reactions. High-throughput experimentation techniques provided successful reaction conditions initially involving phosphites as ligands. Ultimately, 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane was identified as giving a longer-lived catalyst with higher turnover numbers. Its use, in conjunction with a palladacycle precatalyst, led to optimal reaction rates and yields. Scope and limitations of this novel method are presented along with initial mechanistic insight.