127682-76-2

Basic information

• Product Name: 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL
• Synonyms: 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL;(3R,5R)-5-(diMethoxyMethyl)tetrahydrofuran-3-ol
• CAS NO: 127682-76-2
• Molecular Formula: C₇H₁₄O₄
• Molecular Weight: 162.18
• Mol File: 127682-76-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL(127682-76-2)
• EPA Substance Registry System: 5-DIMETHOXYMETHYL-TETRAHYDRO-FURAN-3-OL(127682-76-2)

Safety Data

• Hazardous Substances Data: 127682-76-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 3396-72-3 3-deoxy-1,2-O-(1-methylethylidene)-α-D-erythro-pentofuranose 4-methylbenzenesufonate 
• 89860-19-5 (1R,2R,5R)-2-(dimethoxymethyl)-3,6-dioxabicyclo[3.1.0]hexane 
• 532-20-7 D-xylofuranose 
• 3396-71-2 3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 
• 4105-29-7 [(3aR,5S,6aR)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 
• 20701-43-3 2,5-Anhydro-D-xylose dimethyl acetal 3-(4-methylbenzenesulfonate) 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 

Downstream Products

• 127682-75-1 IsoddA 
• 127682-82-0 (2R-cis)-4-(6-chloro-9H-purin-9-yl)-tetrahydro-2-furanmethanol 
• 127682-78-4 (2R-trans)-tetrahydro-4-[[(4-methylphenyl)-sulfonyl]oxy]-2-furanmethanol 
• 127682-80-8 (2R-cis)-4-aminotetrahydro-2-furanmethanol 
• 127682-82-0 (2R-cis)-4-(6-chloro-9H-purin-9-yl)tetrahydrofuran-2-methanol 
• 127682-78-4 (2R-trans)-tetrahydro-4-<<(4-methylphenyl)sulfonyl>oxy>-2-furanmethanol 
• 127682-80-8 (2R-cis)-4-aminotetrahydro-2-furanmethanol 
• 127682-77-3 (3S-trans)-tetrahydro-5-(dimethoxymethyl)-3-furanol 4-methylbenzenesulfonate 
• 127682-77-3 2(R)-<(dimethoxy)methyl>-4(S)-tetrahydrofuran 

Relevant articles and documents

Synthesis and structural characterization of homochiral homo-oligomers of parent cis- and trans-furanoid-β-amino acids

The synthesis of homochiral homo-oligomers of cis- and trans-3- aminotetrahydrofuran-2-carboxylic acids (parent cis- and trans-furanoid-β- amino acids, referred to as "cis-/trans-FAA") has been carried out to understand their secondary structures and their dependence on the ring heteroatom. The oligomers of two diastereomers have been shown to have a distinct left-handed helicity. The cis-FAA homo-oligomers show a 14-helix structure, in contrast to the homo-oligomers of cis-ACPC, which adopt a sheet like structure. The trans-FAA homo-oligomers were found to adopt a 12-helix structure, the same trend found in trans-ACPC homo-oligomers. With the help of ab initio calculations, the structural features of cis-ACPC and cis-FAA hexamers were compared. We believe that the more compact packing of the cis-FAA hexapeptide should be due to a more favorable interaction between the ring and the backbone amide hydrogen. It's the heteroatom that counts: trans-Furanoid-β-amino acid (FAA) homo-oligomers adopt a 12-helix structure similar to that of trans-ACPC (2-aminocyclopentane carboxylic acid) oligomers. However, cis-FAA oligomers seem to adopt 14-helix solution structures, which is in contrast to cis-ACPC oligomers, for which a sheetlike structure has been observed. Calculations reveal that this preference in cis-FAAs is due to a more favorable contact between the backbone and the ring (see scheme). Copyright

Synthesis of 5-substituted-3-[(2'S,3'S)-3'-hydroxy-2'-hydroxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazoles and their epimers

5-Phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole 10a and its epimer 11a, 5-methyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole 10b and its epimer 11b were synthesized from cyan

Synthesis and anti-HIV activity of isonucleosides

A series of isomeric 2',3'-dideoxynucleosides which contains a modified carbohydrate moiety has been prepared. This class of compounds was designed to mimic the activity of known anti-HIV dideoxynucleosides, while imparting enhanced chemical and enzymatic